ENSMUSG00000024120


Mus musculus

Features
Gene ID: ENSMUSG00000024120
  
Biological name :Lrpprc
  
Synonyms : Leucine-rich PPR motif-containing protein, mitochondrial / Lrpprc / Q6PB66
  
Possible biological names infered from orthology : leucine rich pentatricopeptide repeat containing / P42704
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E4
Gene start: 84705247
Gene end: 84790789
  
Corresponding Affymetrix probe sets: 10453334 (MoGene1.0st)   1424353_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107927
Ensembl peptide - ENSMUSP00000123795
NCBI entrez gene - 72416     See in Manteia.
MGI - MGI:1919666
RefSeq - NM_028233
RefSeq - XM_011246643
RefSeq Peptide - NP_082509
swissprot - F6V2A3
swissprot - Q6PB66
Ensembl - ENSMUSG00000024120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrpprcENSDARG00000043970Danio rerio
 LRPPRCENSGALG00000009967Gallus gallus
 LRPPRCENSG00000138095Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002885  Pentatricopeptide repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR033490  Leucine-rich PPR motif-containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000961 negative regulation of mitochondrial RNA catabolic process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009451 RNA modification IBA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0070129 regulation of mitochondrial translation IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0000794 condensed nuclear chromosome IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005637 nuclear inner membrane IEA
 cellular_componentGO:0005640 nuclear outer membrane IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042645 mitochondrial nucleoid IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IDA
 molecular_functionGO:0003723 RNA binding IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004519 endonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kptntm1a(EUCOMM)Wtsi/Kptntm1a(EUCOMM)Wtsi
Genetic Background: B6JTyr;B6N-Kptntm1a(EUCOMM)Wtsi/Wtsi

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0006207 embryonic lethality during organogenesis "death anytime after embryo turning but before the completion of organogenesis (E9 to less than E14)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crbntm1.2Jjh/Crbntm1.2Jjh
Genetic Background: involves: C57BL/6

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
Show

Allelic Composition: Havcr1tm1Vlcg/Havcr1tm1Vlcg
Genetic Background: C.129-Havcr1tm1Vlcg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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