ENSMUSG00000024210


Mus musculus

Features
Gene ID: ENSMUSG00000024210
  
Biological name :Ip6k3
  
Synonyms : Inositol hexakisphosphate kinase 3 / Ip6k3 / Q8BWD2
  
Possible biological names infered from orthology : Q96PC2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 27143969
Gene end: 27167764
  
Corresponding Affymetrix probe sets: 10449320 (MoGene1.0st)   1443503_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025046
NCBI entrez gene - 271424     See in Manteia.
MGI - MGI:3045325
RefSeq - NM_173027
RefSeq Peptide - NP_766615
swissprot - Q8BWD2
Ensembl - ENSMUSG00000024210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IP6K3ENSGALG00000026536Gallus gallus
 IP6K3ENSG00000161896Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ip6k1 / Q6PD10 / Inositol hexakisphosphate kinase 1 / Q92551*ENSMUSG0000003259449
Ip6k2 / Q80V72 / Inositol hexakisphosphate kinase 2 / Q9UHH9*ENSMUSG0000003259943
Ipmk / Q7TT16 / Mus musculus inositol polyphosphate multikinase (Ipmk), transcript variant 2, mRNA. / Q8NFU5* / inositol polyphosphate multikinase*ENSMUSG0000006073321


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process ISO
 biological_processGO:0046488 phosphatidylinositol metabolic process IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000828 inositol hexakisphosphate kinase activity IEA
 molecular_functionGO:0000831 inositol hexakisphosphate 6-kinase activity IEA
 molecular_functionGO:0000832 inositol hexakisphosphate 5-kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0052723 inositol hexakisphosphate 1-kinase activity IEA
 molecular_functionGO:0052724 inositol hexakisphosphate 3-kinase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of pyrophosphates in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0000890 thin cerebellar molecular layer "reduced width of the outer of the three cortical layers of the cerebellum" [J:46854]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Del(1Aim2-Ifi205)1Stsn/Del(1Aim2-Ifi205)1Stsn,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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