ENSMUSG00000032599


Mus musculus

Features
Gene ID: ENSMUSG00000032599
  
Biological name :Ip6k2
  
Synonyms : Inositol hexakisphosphate kinase 2 / Ip6k2 / Q80V72
  
Possible biological names infered from orthology : Q9UHH9
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F2
Gene start: 108783796
Gene end: 108806337
  
Corresponding Affymetrix probe sets: 10589099 (MoGene1.0st)   1428373_at (Mouse Genome 430 2.0 Array)   1435319_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141242
Ensembl peptide - ENSMUSP00000142277
Ensembl peptide - ENSMUSP00000142239
Ensembl peptide - ENSMUSP00000142134
Ensembl peptide - ENSMUSP00000141831
Ensembl peptide - ENSMUSP00000141605
Ensembl peptide - ENSMUSP00000141515
Ensembl peptide - ENSMUSP00000141461
Ensembl peptide - ENSMUSP00000082091
NCBI entrez gene - 76500     See in Manteia.
MGI - MGI:1923750
RefSeq - XM_006511856
RefSeq - XM_006511855
RefSeq - XM_006511853
RefSeq - NM_029634
RefSeq - XM_006511851
RefSeq - XM_006511850
RefSeq - XM_006511852
RefSeq Peptide - NP_083910
swissprot - A0A0A6YY18
swissprot - Q6PAT6
swissprot - Q80V72
swissprot - A0A0A6YVS3
swissprot - A0A0A6YWA1
swissprot - A0A0A6YWE4
swissprot - A0A0A6YWM3
swissprot - A0A0A6YX46
swissprot - A0A0A6YXT7
Ensembl - ENSMUSG00000032599
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ip6k2aENSDARG00000008310Danio rerio
 ip6k2bENSDARG00000019613Danio rerio
 IP6K2ENSGALG00000005701Gallus gallus
 IP6K2ENSG00000068745Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ip6k1 / Q6PD10 / Inositol hexakisphosphate kinase 1 / Q92551*ENSMUSG0000003259445
Ip6k3 / Q8BWD2 / Inositol hexakisphosphate kinase 3 / Q96PC2*ENSMUSG0000002421038
Ipmk / Q7TT16 / Mus musculus inositol polyphosphate multikinase (Ipmk), transcript variant 2, mRNA. / Q8NFU5* / inositol polyphosphate multikinase*ENSMUSG0000006073321


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006817 phosphate ion transport IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000828 inositol hexakisphosphate kinase activity IEA
 molecular_functionGO:0000832 inositol hexakisphosphate 5-kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0052723 inositol hexakisphosphate 1-kinase activity IEA
 molecular_functionGO:0052724 inositol hexakisphosphate 3-kinase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0003010 decreased mortality induced by ionizing radiation "reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays" [smb:Susan M. Bello , Mouse Genome Informatics Curator, J:88888]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004228 decreased cellular sensitivity to ionizing radiation "decreased incidence of cell death following exposure to high levels of ionizing radiation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004546 esophagus hyperplasia "overdevelopment or increased size, usually due an increased number of cells of the esophagus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm9(cre/ESR1)Arte/?,Tnfaip3tm1Homy/Tnfaip3tm1Homy
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Szt2Gt(XH662)Byg/Szt2m1Frk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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