ENSMUSG00000032594


Mus musculus

Features
Gene ID: ENSMUSG00000032594
  
Biological name :Ip6k1
  
Synonyms : Inositol hexakisphosphate kinase 1 / Ip6k1 / Q6PD10
  
Possible biological names infered from orthology : Q92551
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F1
Gene start: 108002501
Gene end: 108048782
  
Corresponding Affymetrix probe sets: 10588826 (MoGene1.0st)   1422968_at (Mouse Genome 430 2.0 Array)   1422969_s_at (Mouse Genome 430 2.0 Array)   1438845_at (Mouse Genome 430 2.0 Array)   1438846_x_at (Mouse Genome 430 2.0 Array)   1452694_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134754
Ensembl peptide - ENSMUSP00000135350
Ensembl peptide - ENSMUSP00000135587
Ensembl peptide - ENSMUSP00000135747
Ensembl peptide - ENSMUSP00000141232
Ensembl peptide - ENSMUSP00000035214
Ensembl peptide - ENSMUSP00000128534
NCBI entrez gene - 27399     See in Manteia.
MGI - MGI:1351633
RefSeq - NM_013785
RefSeq Peptide - NP_038813
swissprot - Q6PD10
swissprot - A0A0A6YVR5
swissprot - F7CWH3
swissprot - H3BIW9
swissprot - H3BKD8
swissprot - H3BKZ2
swissprot - H3BLD6
Ensembl - ENSMUSG00000032594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ip6k1ENSDARG00000073744Danio rerio
 IP6K1ENSGALG00000002510Gallus gallus
 IP6K1ENSG00000176095Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ip6k2 / Q80V72 / Inositol hexakisphosphate kinase 2 / Q9UHH9*ENSMUSG0000003259946
Ip6k3 / Q8BWD2 / Inositol hexakisphosphate kinase 3 / Q96PC2*ENSMUSG0000002421045
Ipmk / Q7TT16 / Mus musculus inositol polyphosphate multikinase (Ipmk), transcript variant 2, mRNA. / Q8NFU5* / inositol polyphosphate multikinase*ENSMUSG0000006073322


Protein motifs (from Interpro)
Interpro ID Name
 IPR005522  Inositol polyphosphate kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006020 inositol metabolic process ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032958 inositol phosphate biosynthetic process IEA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000828 inositol hexakisphosphate kinase activity IEA
 molecular_functionGO:0000832 inositol hexakisphosphate 5-kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0052723 inositol hexakisphosphate 1-kinase activity IEA
 molecular_functionGO:0052724 inositol hexakisphosphate 3-kinase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of pyrophosphates in the cytosol
Synthesis of IPs in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sharpincpdm/Sharpincpdm
Genetic Background: involves: C57BL/KaLawRij * FVB/NJ

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ip6k1tm1.1Snyd/Ip6k1tm1.1Snyd
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ip6k1tm1.1Snyd/Ip6k1tm1.1Snyd
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Allelic Composition: Ip6k1tm1.1Snyd/Ip6k1tm1.1Snyd
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ip6k1tm1.1Snyd/Ip6k1tm1.1Snyd
Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6

 MP:0013600 testis degeneration "a retrogressive impairment of function or destruction of either or both of the male reproductive glands" [MGI:Anna]
Show

Allelic Composition: Itktm1Lex/Itktm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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