ENSMUSG00000024354


Mus musculus

Features
Gene ID: ENSMUSG00000024354
  
Biological name :Slc23a1
  
Synonyms : Q9Z2J0 / Slc23a1 / Solute carrier family 23 member 1
  
Possible biological names infered from orthology : Q9UHI7
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B2
Gene start: 35614604
Gene end: 35627244
  
Corresponding Affymetrix probe sets: 10458262 (MoGene1.0st)   1421912_at (Mouse Genome 430 2.0 Array)   1450404_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114541
Ensembl peptide - ENSMUSP00000025212
NCBI entrez gene - 20522     See in Manteia.
MGI - MGI:1341903
RefSeq - NM_011397
RefSeq - XM_017317851
RefSeq Peptide - NP_035527
swissprot - D6RDS7
swissprot - Q9Z2J0
Ensembl - ENSMUSG00000024354
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc23a1ENSDARG00000015033Danio rerio
 SLC23A1ENSGALG00000037642Gallus gallus
 Q9UHI7ENSG00000170482Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9EPR4 / Slc23a2 / Mus musculus solute carrier family 23 (nucleobase transporters), member 2 (Slc23a2), transcript variant 2, mRNA. / Q9UGH3* / solute carrier family 23 member 2*ENSMUSG0000002734062
Slc23a3 / solute carrier family 23 member 3 / Q6PIS1*ENSMUSG0000002620527
Slc23a4ENSMUSG0000002984725


Protein motifs (from Interpro)
Interpro ID Name
 IPR006043  Xanthine/uracil/vitamin C permease
 IPR029954  Solute carrier family 23 member 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport ISO
 biological_processGO:0007420 brain development IMP
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0015882 L-ascorbic acid transmembrane transport IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070837 dehydroascorbic acid transport IEA
 biological_processGO:0070904 transepithelial L-ascorbic acid transport IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0043229 intracellular organelle IEA
 molecular_functionGO:0008520 L-ascorbate:sodium symporter activity IEA
 molecular_functionGO:0015081 sodium ion transmembrane transporter activity IEA
 molecular_functionGO:0015229 L-ascorbic acid transmembrane transporter activity IEA
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0033300 dehydroascorbic acid transmembrane transporter activity IEA
 molecular_functionGO:0070890 sodium-dependent L-ascorbate transmembrane transporter activity ISS


Pathways (from Reactome)
Pathway description
Vitamin C (ascorbate) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001671 abnormal vitamin absorption "anomalous ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004019 abnormal vitamin homeostasis "anomaly in the state of equilibrium in the body of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005556 abnormal kidney clearance "altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Papss2bm/Papss2bm
Genetic Background: involves: C57BL/6J * LDJ/Le

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011229 abnormal vitamin C level "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
Show

Allelic Composition: Slc23a1tm1Mlev/Slc23a1tm1Mlev
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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