ENSMUSG00000027340


Mus musculus

Features
Gene ID: ENSMUSG00000027340
  
Biological name :Slc23a2
  
Synonyms : Mus musculus solute carrier family 23 (nucleobase transporters), member 2 (Slc23a2), transcript variant 2, mRNA. / Q9EPR4 / Slc23a2
  
Possible biological names infered from orthology : Q9UGH3 / solute carrier family 23 member 2
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: F2
Gene start: 132052496
Gene end: 132145108
  
Corresponding Affymetrix probe sets: 10487906 (MoGene1.0st)   1417329_at (Mouse Genome 430 2.0 Array)   1417330_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028815
Ensembl peptide - ENSMUSP00000116640
NCBI entrez gene - 54338     See in Manteia.
MGI - MGI:1859682
RefSeq - XM_017319131
RefSeq - NM_001355430
RefSeq - NM_018824
RefSeq - XM_006499906
RefSeq - XM_006499907
RefSeq - XM_011239698
RefSeq Peptide - NP_001342359
RefSeq Peptide - NP_061294
swissprot - A2ANL1
swissprot - Q9EPR4
Ensembl - ENSMUSG00000027340
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc23a2ENSDARG00000017365Danio rerio
 SLC23A2ENSGALG00000000195Gallus gallus
 Q9UGH3ENSG00000089057Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Z2J0 / Slc23a1 / Solute carrier family 23 member 1 / Q9UHI7*ENSMUSG0000002435458
Slc23a3 / solute carrier family 23 member 3 / Q6PIS1*ENSMUSG0000002620526
Slc23a4ENSMUSG0000002984723


Protein motifs (from Interpro)
Interpro ID Name
 IPR006042  Xanthine/uracil permease
 IPR006043  Xanthine/uracil/vitamin C permease
 IPR029956  Solute carrier family 23 member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0015882 L-ascorbic acid transmembrane transport IMP
 biological_processGO:0019852 L-ascorbic acid metabolic process IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070904 transepithelial L-ascorbic acid transport IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0008520 L-ascorbate:sodium symporter activity ISO
 molecular_functionGO:0015229 L-ascorbic acid transmembrane transporter activity IMP
 molecular_functionGO:0015293 symporter activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0070890 sodium-dependent L-ascorbate transmembrane transporter activity ISO


Pathways (from Reactome)
Pathway description
Vitamin C (ascorbate) metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001739 abnormal adrenal secretion "altered ability of the surparenal gland to secrete hormones " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001905 abnormal dopamine level "greater or less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002164 abnormal gland physiology "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0003834 abnormal adrenergic chromaffin cell morphology "malformation of the cells responsible for epinephrine and norepinephrine secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0008291 abnormal adrenocortical cell morphology "any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

 MP:0011229 abnormal vitamin C level "any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species" [GO:0019852]
Show

Allelic Composition: Abcd1tm1Kds/Y,Slc27a2tm1Kds/Slc27a2tm1Kds
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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