ENSMUSG00000024477


Mus musculus

Features
Gene ID: ENSMUSG00000024477
  
Biological name :Pggt1b
  
Synonyms : Geranylgeranyl transferase type-1 subunit beta / Pggt1b / Q8BUY9
  
Possible biological names infered from orthology : P53609 / protein geranylgeranyltransferase type I subunit beta
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: C
Gene start: 46239949
Gene end: 46280850
  
Corresponding Affymetrix probe sets: 10458784 (MoGene1.0st)   1429769_at (Mouse Genome 430 2.0 Array)   1429770_at (Mouse Genome 430 2.0 Array)   1438229_at (Mouse Genome 430 2.0 Array)   1438230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025354
NCBI entrez gene - 225467     See in Manteia.
MGI - MGI:1917514
RefSeq - NM_172627
RefSeq - XM_006525866
RefSeq Peptide - NP_766215
swissprot - Q8BUY9
Ensembl - ENSMUSG00000024477
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pggt1bENSDARG00000103464Danio rerio
 PGGT1BENSGALG00000008197Gallus gallus
 P53609ENSG00000164219Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P53612 / Rabggtb / Rab geranylgeranyl transferase, b subunit / P53611* / Rab geranylgeranyltransferase beta subunit*ENSMUSG0000003897525


Protein motifs (from Interpro)
Interpro ID Name
 IPR001330  PFTB repeat
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0018344 protein geranylgeranylation IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0045787 positive regulation of cell cycle IEA
 biological_processGO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA
 cellular_componentGO:0005953 CAAX-protein geranylgeranyltransferase complex IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004659 prenyltransferase activity IEA
 molecular_functionGO:0004661 protein geranylgeranyltransferase activity IEA
 molecular_functionGO:0004662 CAAX-protein geranylgeranyltransferase activity ISS
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019840 isoprenoid binding IEA
 molecular_functionGO:0042277 peptide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000379 reduced hair follicle number "fewer number of the epidermal invaginations from which the hair shaft develops" [J:15108]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.1Mbrg,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0000382 underdeveloped hair follicles "arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.1Mbrg,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
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Allelic Composition: Pggt1btm1Mbrg/Pggt1btm1Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.1Mbrg,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Tg(KRT14-cre)1Amc/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0006382 abnormal lung epithelium morphology "any structural anomaly of the epithelial layer of the lung" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1btm1Mbrg,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Allelic Composition: Krastm4Tyj/Kras+,Pggt1btm1Mbrg/Pggt1b+,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Ins2C95S/Ins2+
Genetic Background: C3HeB/FeJ-Ins2C95S

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Fntbtm1.1Mbrg/Fntbtm1.2Mbrg,Krastm4Tyj/Kras+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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