ENSMUSG00000024493


Mus musculus

Features
Gene ID: ENSMUSG00000024493
  
Biological name :Lars
  
Synonyms : Lars / Leucine--tRNA ligase, cytoplasmic / Q8BMJ2
  
Possible biological names infered from orthology : leucyl-tRNA synthetase / Q9P2J5
  
Species: Mus musculus
  
Chr. number: 18
Strand: -1
Band: B3
Gene start: 42202350
Gene end: 42262122
  
Corresponding Affymetrix probe sets: 10458607 (MoGene1.0st)   1448403_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095197
NCBI entrez gene - 107045     See in Manteia.
MGI - MGI:1913808
RefSeq - NM_134137
RefSeq Peptide - NP_598898
swissprot - Q7TSZ3
swissprot - Q8BMJ2
Ensembl - ENSMUSG00000024493
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 larsaENSDARG00000090988Danio rerio
 larsbENSDARG00000019280Danio rerio
 LARSENSGALG00000007494Gallus gallus
 LARSENSG00000133706Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001412  Aminoacyl-tRNA synthetase, class I, conserved site
 IPR002300  Aminoacyl-tRNA synthetase, class Ia
 IPR004493  Leucyl-tRNA synthetase, class Ia, archaeal/eukaryotic cytosolic
 IPR009008  Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
 IPR009080  Aminoacyl-tRNA synthetase, class Ia, anticodon-binding
 IPR013155  Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006418 tRNA aminoacylation for protein translation IEA
 biological_processGO:0006425 glutaminyl-tRNA aminoacylation ISO
 biological_processGO:0006429 leucyl-tRNA aminoacylation IDA
 biological_processGO:0006438 valyl-tRNA aminoacylation IBA
 biological_processGO:0006622 protein targeting to lysosome IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0034198 cellular response to amino acid starvation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0071230 cellular response to amino acid stimulus IEA
 biological_processGO:0071233 cellular response to leucine IEA
 biological_processGO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity IEA
 biological_processGO:1904263 positive regulation of TORC1 signaling IEA
 biological_processGO:1990253 cellular response to leucine starvation IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0017101 aminoacyl-tRNA synthetase multienzyme complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002161 aminoacyl-tRNA editing activity IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004819 glutamine-tRNA ligase activity ISO
 molecular_functionGO:0004823 leucine-tRNA ligase activity IMP
 molecular_functionGO:0004832 valine-tRNA ligase activity IBA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Krit1tm1.1(KOMP)Vlcg/Krit1+
Genetic Background: C57BL/6N-Krit1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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