ENSMUSG00000024561


Mus musculus

Features
Gene ID: ENSMUSG00000024561
  
Biological name :Mbd1
  
Synonyms : Mbd1 / Mus musculus methyl-CpG binding domain protein 1 (Mbd1), transcript variant 4, mRNA.
  
Possible biological names infered from orthology : methyl-CpG binding domain protein 1 / Q9UIS9
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 74267605
Gene end: 74282732
  
Corresponding Affymetrix probe sets: 10456622 (MoGene1.0st)   1417968_a_at (Mouse Genome 430 2.0 Array)   1430837_a_at (Mouse Genome 430 2.0 Array)   1430838_x_at (Mouse Genome 430 2.0 Array)   1437061_at (Mouse Genome 430 2.0 Array)   1453678_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153085
Ensembl peptide - ENSMUSP00000153428
Ensembl peptide - ENSMUSP00000095137
NCBI entrez gene - 17190     See in Manteia.
MGI - MGI:1333811
RefSeq - XM_017317847
RefSeq - XM_006525708
RefSeq - XM_006525709
RefSeq - XM_017317844
RefSeq - XM_017317845
RefSeq - XM_017317846
RefSeq - NM_001357423
RefSeq - NM_013594
RefSeq - XM_006525704
RefSeq - XM_006525705
RefSeq - XM_006525706
RefSeq - XM_006525707
RefSeq Peptide - NP_038622
RefSeq Peptide - NP_001344352
swissprot - A0A286YDI1
swissprot - A0A286YCP6
swissprot - A0A0R4J159
Ensembl - ENSMUSG00000024561
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbd1aENSDARG00000101205Danio rerio
 mbd1bENSDARG00000025699Danio rerio
 MBD1ENSG00000141644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001739  Methyl-CpG DNA binding
 IPR002857  Zinc finger, CXXC-type
 IPR016177  DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008327 methyl-CpG binding IEA
 molecular_functionGO:0010385 double-stranded methylated DNA binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of transcription cofactors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0008866 chromosomal instability "abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", PMID:12446840]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fasntm1Schi/Fasn+
Genetic Background: 129S7/SvEvBrd-Fasntm1Schi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015120 Ube2i / P63280 / ubiquitin-conjugating enzyme E2I / P63279*  / reaction
 ENSMUSG00000026021 Sumo1 / P63166 / Small ubiquitin-related modifier 1 / P63165* / small ubiquitin-like modifier 1*  / complex / reaction






 

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