ENSMUSG00000024892


Mus musculus

Features
Gene ID: ENSMUSG00000024892
  
Biological name :Pcx
  
Synonyms : Pcx / pyruvate carboxylase
  
Possible biological names infered from orthology : P11498 / PC
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 4510472
Gene end: 4621752
  
Corresponding Affymetrix probe sets: 10460400 (MoGene1.0st)   1416383_a_at (Mouse Genome 430 2.0 Array)   AFFX-PyruCarbMur/L09192_3_at (Mouse Genome 430 2.0 Array)   AFFX-PyruCarbMur/L09192_5_at (Mouse Genome 430 2.0 Array)   AFFX-PyruCarbMur/L09192_MA_at (Mouse Genome 430 2.0 Array)   AFFX-PyruCarbMur/L09192_MB_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153479
Ensembl peptide - ENSMUSP00000063825
Ensembl peptide - ENSMUSP00000109456
Ensembl peptide - ENSMUSP00000152918
NCBI entrez gene - 18563     See in Manteia.
MGI - MGI:97520
RefSeq - XM_006531678
RefSeq - NM_001162946
RefSeq - NM_008797
RefSeq Peptide - NP_032823
RefSeq Peptide - NP_001156418
swissprot - A0A286YCC5
swissprot - G5E8R3
swissprot - E9QPD7
Ensembl - ENSMUSG00000024892
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pcxaENSDARG00000098766Danio rerio
 pcxbENSDARG00000051939Danio rerio
 PCENSG00000173599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000089  Biotin/lipoyl attachment
 IPR000891  Pyruvate carboxyltransferase
 IPR001882  Biotin-binding site
 IPR003379  Carboxylase, conserved domain
 IPR005479  Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
 IPR005481  Biotin carboxylase-like, N-terminal domain
 IPR005482  Biotin carboxylase, C-terminal
 IPR005930  Pyruvate carboxylase
 IPR011053  Single hybrid motif
 IPR011054  Rudiment single hybrid motif
 IPR011761  ATP-grasp fold
 IPR011764  Biotin carboxylation domain
 IPR013785  Aldolase-type TIM barrel
 IPR013815  ATP-grasp fold, subdomain 1
 IPR016185  Pre-ATP-grasp domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006090 pyruvate metabolic process IEA
 biological_processGO:0006094 gluconeogenesis IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0019074 viral RNA genome packaging IEA
 biological_processGO:0044791 positive regulation by host of viral release from host cell IEA
 biological_processGO:0044794 positive regulation by host of viral process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004075 biotin carboxylase activity IEA
 molecular_functionGO:0004736 pyruvate carboxylase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0009374 biotin binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Biotin transport and metabolism
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pcsk1tm1b(EUCOMM)Wtsi/Pcsk1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcsk1tm1b(EUCOMM)Wtsi/Ics

Allelic Composition: Pcxtm1b(EUCOMM)Wtsi/Pcxtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pcxtm1b(EUCOMM)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024892 Pcx / pyruvate carboxylase / PC* / P11498*  / complex
 ENSMUSG00000040820 Hlcs / Q920N2 / holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) / P50747* / holocarboxylase synthetase*  / reaction






 

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