ENSMUSG00000024921


Mus musculus

Features
Gene ID: ENSMUSG00000024921
  
Biological name :Smarca2
  
Synonyms : Smarca2 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
  
Possible biological names infered from orthology : P51531
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C1
Gene start: 26605050
Gene end: 26778322
  
Corresponding Affymetrix probe sets: 10462237 (MoGene1.0st)   1430526_a_at (Mouse Genome 430 2.0 Array)   1452333_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146432
Ensembl peptide - ENSMUSP00000147244
Ensembl peptide - ENSMUSP00000147173
Ensembl peptide - ENSMUSP00000146994
Ensembl peptide - ENSMUSP00000146971
Ensembl peptide - ENSMUSP00000146924
Ensembl peptide - ENSMUSP00000146919
Ensembl peptide - ENSMUSP00000146890
Ensembl peptide - ENSMUSP00000146875
Ensembl peptide - ENSMUSP00000146859
Ensembl peptide - ENSMUSP00000146770
Ensembl peptide - ENSMUSP00000146632
Ensembl peptide - ENSMUSP00000146630
Ensembl peptide - ENSMUSP00000146626
Ensembl peptide - ENSMUSP00000146616
Ensembl peptide - ENSMUSP00000146493
Ensembl peptide - ENSMUSP00000146464
Ensembl peptide - ENSMUSP00000146442
Ensembl peptide - ENSMUSP00000025862
Ensembl peptide - ENSMUSP00000097135
Ensembl peptide - ENSMUSP00000108256
Ensembl peptide - ENSMUSP00000134914
Ensembl peptide - ENSMUSP00000134995
Ensembl peptide - ENSMUSP00000135017
Ensembl peptide - ENSMUSP00000135042
Ensembl peptide - ENSMUSP00000135248
Ensembl peptide - ENSMUSP00000135344
Ensembl peptide - ENSMUSP00000135412
Ensembl peptide - ENSMUSP00000135460
Ensembl peptide - ENSMUSP00000135784
Ensembl peptide - ENSMUSP00000135800
Ensembl peptide - ENSMUSP00000146379
Ensembl peptide - ENSMUSP00000146392
NCBI entrez gene - 67155     See in Manteia.
MGI - MGI:99603
RefSeq - NM_026003
RefSeq - XM_017318278
RefSeq - XM_017318276
RefSeq - XM_017318277
RefSeq - NM_011416
RefSeq - XM_006527281
RefSeq - XM_006527282
RefSeq - XM_006527283
RefSeq - XM_006527284
RefSeq - XM_006527285
RefSeq - XM_006527286
RefSeq - XM_006527288
RefSeq - XM_006527289
RefSeq - XM_006527291
RefSeq - XM_017318275
RefSeq Peptide - NP_035546
RefSeq Peptide - NP_080279
RefSeq Peptide - NP_001334368
swissprot - H3BJK2
swissprot - H3BJM2
swissprot - H3BK47
swissprot - H3BKD2
swissprot - E9QAB8
swissprot - H3BKN5
swissprot - H3BLH0
swissprot - H3BLI4
swissprot - Q9D007
swissprot - H3BKJ3
swissprot - A0A140LJK1
swissprot - A0A140LJD7
swissprot - A0A140LIV3
swissprot - A0A140LIQ9
swissprot - A0A140LIM0
swissprot - A0A140LIK7
swissprot - A0A140LID0
swissprot - A0A140LI14
swissprot - A0A140LI12
swissprot - A0A140LI08
swissprot - A0A140LHZ8
swissprot - A0A140LHP6
swissprot - A0A140LHL7
swissprot - A0A140LHJ8
swissprot - A0A140LHF4
swissprot - A0A140LHE2
swissprot - F2Z4A9
swissprot - H3BJI1
Ensembl - ENSMUSG00000024921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smarca2ENSDARG00000008904Danio rerio
 SMARCA2ENSGALG00000010164Gallus gallus
 P51531ENSG00000080503Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3TKT4 / Smarca4 / SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 / P51532*ENSMUSG0000003218776


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001487  Bromodomain
 IPR001650  Helicase, C-terminal
 IPR006576  BRK domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014012  Helicase/SANT-associated domain
 IPR014978  Glutamine-Leucine-Glutamine, QLQ
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR018359  Bromodomain, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR029295  Snf2, ATP coupling domain
 IPR030088  SWI/SNF complex subunit SMARCA2
 IPR036427  Bromodomain-like superfamily
 IPR037259  BRK domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007286 spermatid development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016514 SWI/SNF complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016817 hydrolase activity, acting on acid anhydrides IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042393 histone binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2+,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2+,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0001237 enlarged spinous cells "increased size of the cells of the spinous layer of the epidermis" [J:47225]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0001239 abnormal granular layer morphology "structural or developmental anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
Show

Allelic Composition: Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: RhoNoerg1/Rho+
Genetic Background: C57BL/6J-RhoNoerg1/Nwu

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.1Pcn/Smarca4+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002731 megacolon "extreme dilation of the colon" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:40722]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2+,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.2Pcn,Tg(KRT14-cre/ERT2)1Ipc/?
Genetic Background: involves: 129S2/SvPas

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1

 MP:0008802 abnormal intestinal smooth muscle morphology "any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0009476 enlarged cecum "increased size of the large sac at the ileum and large intestine junction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2+,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rb1tm1Tyj/Rb1+,Smarca4tm1Mag/Smarca4+
Genetic Background: involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2tm1Mya,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0013956 decreased colon length "reduced length of the portion of the large intestine between the cecum and the rectum" [ISBN:0683400088]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2+,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

 MP:0013958 decreased small intestine length "reduced length of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum" [ISBN:0683400088]
Show

Allelic Composition: Smarca2tm1Mya/Smarca2+,Smarca4tm1.2Pcn/Smarca4tm1.1Pcn,Tg(Myh11-cre,-EGFP)2Mik/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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