ENSMUSG00000024943


Mus musculus

Features
Gene ID: ENSMUSG00000024943
  
Biological name :Smc5
  
Synonyms : Q8CG46 / Smc5 / Structural maintenance of chromosomes protein 5
  
Possible biological names infered from orthology : Q8IY18 / structural maintenance of chromosomes 5
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: B
Gene start: 23206451
Gene end: 23273897
  
Corresponding Affymetrix probe sets: 10466682 (MoGene1.0st)   1426270_at (Mouse Genome 430 2.0 Array)   1426271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084837
Ensembl peptide - ENSMUSP00000153364
Ensembl peptide - ENSMUSP00000153420
NCBI entrez gene - 226026     See in Manteia.
MGI - MGI:2385088
RefSeq - XM_006526981
RefSeq - NM_001252684
RefSeq - NM_001252685
RefSeq - NM_153808
RefSeq - XM_006526980
RefSeq Peptide - NP_001239614
RefSeq Peptide - NP_722503
RefSeq Peptide - NP_001239613
swissprot - Q8CG46
swissprot - A0A286YDG5
Ensembl - ENSMUSG00000024943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smc5ENSDARG00000044282Danio rerio
 SMC5ENSGALG00000015118Gallus gallus
 SMC5ENSG00000198887Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR027131  Structural maintenance of chromosomes protein 5
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000722 telomere maintenance via recombination IEA
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007062 sister chromatid cohesion IEA
 biological_processGO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051984 positive regulation of chromosome segregation IEA
 biological_processGO:0090398 cellular senescence IEA
 cellular_componentGO:0000781 chromosome, telomeric region IMP
 cellular_componentGO:0000803 sex chromosome IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016605 PML body IMP
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030915 Smc5-Smc6 complex IEA
 cellular_componentGO:0035061 interchromatin granule IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

 MP:0004760 increased mitotic index "increased number of cells in G2/M phase" [Bertram_Weiss:Bayer_Schering_Pharma_AG]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Yy1tm2.1Yshi/Yy1tm2.1Yshi,Tg(Nkx2-1-cre)2Sand/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009567 mitotic nondisjuction "failure of sister-chromatids to separate to the cell poles at anaphase" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

 MP:0009762 abnormal mitotic spindle assembly checkpoint "an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules" [PMID:19372138]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Slc6a3tm1b(KOMP)Wtsi/Slc6a3+
Genetic Background: C57BL/6N-Slc6a3tm1b(KOMP)Wtsi/J

 MP:0012556 increased cell death "increased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
Show

Allelic Composition: Gt(ROSA)26Sortm1(cre/ERT2)Tyj/0,Smc5tm1c(KOMP)Wtsi/Smc5tm1d(KOMP)Wtsi
Genetic Background: involves: 129S4/SvJae * C57BL/6N * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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