ENSMUSG00000025194


Mus musculus

Features
Gene ID: ENSMUSG00000025194
  
Biological name :Abcc2
  
Synonyms : Abcc2 / Canalicular multispecific organic anion transporter 1 / Q8VI47
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 2 / Q92887
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 43782192
Gene end: 43840740
  
Corresponding Affymetrix probe sets: 10463308 (MoGene1.0st)   10463343 (MoGene1.0st)   1450109_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026208
Ensembl peptide - ENSMUSP00000097010
NCBI entrez gene - 12780     See in Manteia.
MGI - MGI:1352447
RefSeq - XM_006526625
RefSeq - NM_013806
RefSeq Peptide - NP_038834
swissprot - Q3UNY3
swissprot - Q8VI47
Ensembl - ENSMUSG00000025194
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc2ENSDARG00000014031Danio rerio
 ABCC2ENSGALG00000007395Gallus gallus
 ABCC2ENSG00000023839Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcc1 / O35379 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / P33527* / ATP binding cassette subfamily C member 1*ENSMUSG0000002308846
Abcc3 / ATP binding cassette subfamily C member 3 / O15438*ENSMUSG0000002086545
Abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4 / O15439* / ATP binding cassette subfamily C member 4*ENSMUSG0000003284931
Abcc9 / P70170 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / ATP binding cassette subfamily C member 9*ENSMUSG0000003024930
Abcc5 / Q9R1X5 / Multidrug resistance-associated protein 5 / O15440* / ATP binding cassette subfamily C member 5*ENSMUSG0000002282230
Abcc12 / Q80WJ6 / Multidrug resistance-associated protein 9 / Q96J65* / ATP binding cassette subfamily C member 12*ENSMUSG0000003687226
Cftr / P26361 / Cystic fibrosis transmembrane conductance regulator / P13569*ENSMUSG0000004130124


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005292  Multi drug resistance-associated protein
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030247  Canalicular multispecific organic anion transporter 1
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0015694 mercury ion transport IEA
 biological_processGO:0015722 canalicular bile acid transport IEA
 biological_processGO:0015732 prostaglandin transport IEA
 biological_processGO:0016999 antibiotic metabolic process IEA
 biological_processGO:0030644 cellular chloride ion homeostasis IEA
 biological_processGO:0031427 response to methotrexate IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IBA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0046685 response to arsenic-containing substance IEA
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0055085 transmembrane transport IBA
 biological_processGO:0070327 thyroid hormone transport IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0097327 response to antineoplastic agent IEA
 biological_processGO:1901086 benzylpenicillin metabolic process IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0046581 intercellular canaliculus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IBA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0002966 decreased circulating alkaline phosphatase level "reduced activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004773 abnormal bile composition "any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: FVB.129P2-Abcc2tm1Ahs

Allelic Composition: Abcc2tm1Dgen/Abcc2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: B6.129P2(FVB)-Abcc2tm1Ahs

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcc2tm2b(KOMP)Wtsi/Abcc2tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Abcc2tm2b(KOMP)Wtsi/H

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: B6.129P2(FVB)-Abcc2tm1Ahs

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: FVB.129P2-Abcc2tm1Ahs

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor,Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: FVB.129P2-Abcb1btm1Bor Abcb1atm1Bor Abcc2tm1Ahs

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0011464 bilirubinuria "presence of conjugated bilirubin in the urine" [MGI:csmith]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

Allelic Composition: Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: FVB.129P2-Abcc2tm1Ahs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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