ENSMUSG00000032849


Mus musculus

Features
Gene ID: ENSMUSG00000032849
  
Biological name :Abcc4
  
Synonyms : Abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 4 / O15439
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: E4
Gene start: 118482692
Gene end: 118706219
  
Corresponding Affymetrix probe sets: 10422280 (MoGene1.0st)   1443870_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129677
Ensembl peptide - ENSMUSP00000042186
NCBI entrez gene - 239273     See in Manteia.
MGI - MGI:2443111
RefSeq - NM_001033336
RefSeq - NM_001163675
RefSeq - NM_001163676
RefSeq Peptide - NP_001157147
RefSeq Peptide - NP_001157148
RefSeq Peptide - NP_001028508
swissprot - E9Q467
swissprot - E9Q236
Ensembl - ENSMUSG00000032849
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc4ENSDARG00000058953Danio rerio
 ABCC4ENSGALG00000016896Gallus gallus
 ABCC4ENSG00000125257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcc1 / O35379 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / P33527* / ATP binding cassette subfamily C member 1*ENSMUSG0000002308836
Abcc2 / Q8VI47 / Canalicular multispecific organic anion transporter 1 / Q92887* / ATP binding cassette subfamily C member 2*ENSMUSG0000002519436
Abcc3 / ATP binding cassette subfamily C member 3 / O15438*ENSMUSG0000002086535
Abcc5 / Q9R1X5 / Multidrug resistance-associated protein 5 / O15440* / ATP binding cassette subfamily C member 5*ENSMUSG0000002282234
Abcc12 / Q80WJ6 / Multidrug resistance-associated protein 9 / Q96J65* / ATP binding cassette subfamily C member 12*ENSMUSG0000003687234
Cftr / P26361 / Cystic fibrosis transmembrane conductance regulator / P13569*ENSMUSG0000004130133
Abcc9 / P70170 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / ATP binding cassette subfamily C member 9*ENSMUSG0000003024931


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030240  Multidrug resistance-associated protein 4
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport TAS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0032310 prostaglandin secretion ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060271 cilium assembly ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0031088 platelet dense granule membrane ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015132 prostaglandin transmembrane transporter activity ISO
 molecular_functionGO:0015238 drug transmembrane transporter activity TAS
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0000711 thymic cortex hypoplasia "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0001858 intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

 MP:0002356 abnormal spleen red pulp morphology "anomalous structure of the area of the spleen that screens and eliminates defective or foreign cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Glra1tm1Betz/Glra1tm1Betz
Genetic Background: B6.129P2-Glra1tm1Betz

 MP:0003306 small intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic Background: B6.129-Abcc4tm1Kruh

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic Background: B6.129-Abcc4tm1Kruh

 MP:0006088 abnormal blood-cerebrospinal fluid barrier "anomaly in the structure or function of the group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92788]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0006272 abnormal renal organic anion excretion "anomaly in the ability of the kidneys to elimiate organic acids (represented by the prototypical substrate para-aminohippurate (PAH))" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:108655]
Show

Allelic Composition: Stat5btm1Mam/Stat5btm1Mam,Tg(Wap-cre)11738Mam/0
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic Background: B6.129-Abcc4tm1Kruh

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic Background: B6.129-Abcc4tm1Kruh

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic Background: B6.129-Abcc4tm1Kruh

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc4tm1Kruh/Abcc4tm1Kruh
Genetic Background: B6.129-Abcc4tm1Kruh

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: B6.129S-Serpine1tm1Mlg Ldlrtm1Her

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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