Manteia - Molecule gene

ENSMUSG00000020865

Mus musculus

Features

Gene ID:	ENSMUSG00000020865

Biological name :	Abcc3

Synonyms :	Abcc3 / ATP binding cassette subfamily C member 3

Possible biological names infered from orthology :	O15438

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	D
Gene start:	94343295
Gene end:	94392997

Corresponding Affymetrix probe sets:	10389894 (MoGene1.0st) 1428988_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000021231 Ensembl peptide - ENSMUSP00000136343 NCBI entrez gene - 76408 See in Manteia. MGI - MGI:1923658 RefSeq - XM_006534428 RefSeq - NM_029600 RefSeq Peptide - NP_083876 swissprot - A0A0R4J015 swissprot - J3QML2 Ensembl - ENSMUSG00000020865

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
abcc3	ENSDARG00000096662	Danio rerio
ABCC3	ENSGALG00000007522	Gallus gallus
ABCC3	ENSG00000108846	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Abcc1 / O35379 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / P33527* / ATP binding cassette subfamily C member 1*	ENSMUSG00000023088	56
Abcc2 / Q8VI47 / Canalicular multispecific organic anion transporter 1 / Q92887* / ATP binding cassette subfamily C member 2*	ENSMUSG00000025194	45
Abcc9 / P70170 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / ATP binding cassette subfamily C member 9*	ENSMUSG00000030249	32
Abcc5 / Q9R1X5 / Multidrug resistance-associated protein 5 / O15440* / ATP binding cassette subfamily C member 5*	ENSMUSG00000022822	31
Abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4 / O15439* / ATP binding cassette subfamily C member 4*	ENSMUSG00000032849	30
Abcc12 / Q80WJ6 / Multidrug resistance-associated protein 9 / Q96J65* / ATP binding cassette subfamily C member 12*	ENSMUSG00000036872	29
Cftr / P26361 / Cystic fibrosis transmembrane conductance regulator / P13569*	ENSMUSG00000041301	23

Protein motifs (from Interpro)

Interpro ID	Name
IPR003439	ABC transporter-like
IPR003593	AAA+ ATPase domain
IPR005292	Multi drug resistance-associated protein
IPR011527	ABC transporter type 1, transmembrane domain
IPR017871	ABC transporter, conserved site
IPR027417	P-loop containing nucleoside triphosphate hydrolase
IPR036640	ABC transporter type 1, transmembrane domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0055085	transmembrane transport	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005524	ATP binding	IEA
molecular_function	GO:0016887	ATPase activity	IEA
molecular_function	GO:0022857	transmembrane transporter activity	IEA
molecular_function	GO:0042626	ATPase activity, coupled to transmembrane movement of substances	IEA

Pathways (from Reactome)

Pathway description

Recycling of bile acids and salts

ABC-family proteins mediated transport

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0001982	reduced chemically-elicited antinociception	"less than the normal analgesic effect of chemical substances" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Rb1^tm1Tyj/Rb1^tm1Tyj,Rbl1^tm1Tyj/Rbl1^tm1Tyj Genetic Background: involves: 129S2/SvPas * C57BL/6
MP:0004774	abnormal bile salt level	"anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dnd1^Ter/Dnd1⁺ Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005344	increased circulating bilirubin level	"greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]	Show Allelic Composition: Dnd1^Ter/Dnd1⁺ Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0005365	abnormal bile salt homeostasis	"anomalous regulation of the steroid salts derived from cholesterol in the liver and which play an important role in the digestion and absorption of fats" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86154]	Show Allelic Composition: Rb1^tm1Tyj/Rb1^tm1Tyj,Rbl1^tm1Tyj/Rbl1^tm1Tyj Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Abcc3^tm1Kruh/Abcc3^tm1Kruh,Slc51a^tm1Pda/Slc51a^tm1Pda Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
MP:0008875	abnormal pharmacokinetics of xenobiotics	"any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rb1^tm1Tyj/Rb1^tm1Tyj,Rbl1^tm1Tyj/Rbl1^tm1Tyj Genetic Background: involves: 129S2/SvPas * C57BL/6 Allelic Composition: Abcc3^tm1Bor/Abcc3^tm1Bor Genetic Background: FVB.129P2-Abcc3^tm1Bor

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr