ENSG00000108846


Homo sapiens

Features
Gene ID: ENSG00000108846
  
Biological name :ABCC3
  
Synonyms : ABCC3 / ATP binding cassette subfamily C member 3 / O15438
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q21.33
Gene start: 50634777
Gene end: 50692252
  
Corresponding Affymetrix probe sets: 208161_s_at (Human Genome U133 Plus 2.0 Array)   209641_s_at (Human Genome U133 Plus 2.0 Array)   214979_at (Human Genome U133 Plus 2.0 Array)   230682_x_at (Human Genome U133 Plus 2.0 Array)   239217_x_at (Human Genome U133 Plus 2.0 Array)   242553_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425697
Ensembl peptide - ENSP00000424981
Ensembl peptide - ENSP00000427073
Ensembl peptide - ENSP00000427521
Ensembl peptide - ENSP00000285238
Ensembl peptide - ENSP00000395160
Ensembl peptide - ENSP00000421755
Ensembl peptide - ENSP00000422058
Ensembl peptide - ENSP00000422786
NCBI entrez gene - 8714     See in Manteia.
OMIM - 604323
RefSeq - XM_017025266
RefSeq - NM_001144070
RefSeq - NM_003786
RefSeq - XM_005257763
RefSeq - XM_011525422
RefSeq - XM_011525423
RefSeq - XM_011525424
RefSeq - XM_011525425
RefSeq - XM_017025265
RefSeq Peptide - NP_001137542
RefSeq Peptide - NP_003777
swissprot - H0Y8T5
swissprot - H0Y9T4
swissprot - D6RJE5
swissprot - D6RAB7
swissprot - O15438
swissprot - H0Y8Q6
Ensembl - ENSG00000108846
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc3ENSDARG00000096662Danio rerio
 ABCC3ENSGALG00000007522Gallus gallus
 Abcc3ENSMUSG00000020865Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCC1 / P33527 / ATP binding cassette subfamily C member 1ENSG0000010322257
ABCC2 / Q92887 / ATP binding cassette subfamily C member 2ENSG0000002383946
ABCC9 / O60706 / ATP binding cassette subfamily C member 9ENSG0000006943132
ABCC8 / Q09428 / ATP binding cassette subfamily C member 8ENSG0000000607131
ABCC4 / O15439 / ATP binding cassette subfamily C member 4ENSG0000012525730
ABCC5 / O15440 / ATP binding cassette subfamily C member 5ENSG0000011477030
ABCC12 / Q96J65 / ATP binding cassette subfamily C member 12ENSG0000014079828
ABCC11 / Q96J66 / ATP binding cassette subfamily C member 11ENSG0000012127028
CFTR / P13569 / cystic fibrosis transmembrane conductance regulatorENSG0000000162623


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005292  Multi drug resistance-associated protein
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IBA
 biological_processGO:0015721 bile acid and bile salt transport TAS
 biological_processGO:0015722 canalicular bile acid transport ISS
 biological_processGO:0042908 xenobiotic transport IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0099133 ATP hydrolysis coupled anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008514 organic anion transmembrane transporter activity TAS
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity IBA
 molecular_functionGO:0015432 bile acid-exporting ATPase activity TAS
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0043225 ATPase-coupled anion transmembrane transporter activity TAS


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr