ENSG00000103222


Homo sapiens

Features
Gene ID: ENSG00000103222
  
Biological name :ABCC1
  
Synonyms : ABCC1 / ATP binding cassette subfamily C member 1 / P33527
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.11
Gene start: 15949577
Gene end: 16143074
  
Corresponding Affymetrix probe sets: 202804_at (Human Genome U133 Plus 2.0 Array)   202805_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000461615
Ensembl peptide - ENSP00000382340
Ensembl peptide - ENSP00000382342
Ensembl peptide - ENSP00000459693
NCBI entrez gene - 4363     See in Manteia.
OMIM - 158343
RefSeq - XM_017023242
RefSeq - XM_017023237
RefSeq - XM_017023238
RefSeq - XM_017023239
RefSeq - XM_017023240
RefSeq - XM_017023241
RefSeq - NM_004996
RefSeq - XM_011522497
RefSeq - XM_011522498
RefSeq Peptide - NP_004987
swissprot - I3L2H9
swissprot - I3L4X2
swissprot - A0A0A0MS99
swissprot - P33527
Ensembl - ENSG00000103222
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc1ENSDARG00000104719Danio rerio
 ABCC1ENSGALG00000006646Gallus gallus
 Abcc1ENSMUSG00000023088Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCC3 / O15438 / ATP binding cassette subfamily C member 3ENSG0000010884656
ABCC2 / Q92887 / ATP binding cassette subfamily C member 2ENSG0000002383948
ABCC9 / O60706 / ATP binding cassette subfamily C member 9ENSG0000006943132
ABCC4 / O15439 / ATP binding cassette subfamily C member 4ENSG0000012525732
ABCC8 / Q09428 / ATP binding cassette subfamily C member 8ENSG0000000607132
ABCC5 / O15440 / ATP binding cassette subfamily C member 5ENSG0000011477031
ABCC12 / Q96J65 / ATP binding cassette subfamily C member 12ENSG0000014079830
ABCC11 / Q96J66 / ATP binding cassette subfamily C member 11ENSG0000012127028
CFTR / P13569 / cystic fibrosis transmembrane conductance regulatorENSG0000000162623


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005292  Multi drug resistance-associated protein
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006691 leukotriene metabolic process TAS
 biological_processGO:0006855 drug transmembrane transport IBA
 biological_processGO:0009235 cobalamin metabolic process TAS
 biological_processGO:0015889 cobalamin transport IEA
 biological_processGO:0034775 glutathione transmembrane transport IBA
 biological_processGO:0042493 response to drug TAS
 biological_processGO:0042908 xenobiotic transport IBA
 biological_processGO:0045332 phospholipid translocation IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060326 cell chemotaxis ISS
 biological_processGO:0099039 sphingolipid translocation IMP
 biological_processGO:0099133 ATP hydrolysis coupled anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004012 phospholipid-translocating ATPase activity IMP
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity IBA
 molecular_functionGO:0015420 cobalamin-transporting ATPase activity TAS
 molecular_functionGO:0015431 glutathione S-conjugate-exporting ATPase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0034634 glutathione transmembrane transporter activity IBA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0043225 ATPase-coupled anion transmembrane transporter activity TAS
 molecular_functionGO:0046623 sphingolipid-translocating ATPase activity IMP


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism
Synthesis of Leukotrienes (LT) and Eoxins (EX)
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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