ENSMUSG00000023088


Mus musculus

Features
Gene ID: ENSMUSG00000023088
  
Biological name :Abcc1
  
Synonyms : Abcc1 / ATP-binding cassette, sub-family C (CFTR/MRP), member 1 / O35379
  
Possible biological names infered from orthology : ATP binding cassette subfamily C member 1 / P33527
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 14361558
Gene end: 14475737
  
Corresponding Affymetrix probe sets: 10433735 (MoGene1.0st)   1421378_s_at (Mouse Genome 430 2.0 Array)   1452233_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000115627
Ensembl peptide - ENSMUSP00000122656
Ensembl peptide - ENSMUSP00000120933
Ensembl peptide - ENSMUSP00000116726
Ensembl peptide - ENSMUSP00000116714
Ensembl peptide - ENSMUSP00000115763
Ensembl peptide - ENSMUSP00000097743
NCBI entrez gene - 17250     See in Manteia.
MGI - MGI:102676
RefSeq - XM_017316888
RefSeq - NM_008576
RefSeq - XM_006521839
RefSeq Peptide - NP_032602
swissprot - D3Z407
swissprot - E9Q1I5
swissprot - A5D6P3
swissprot - O35379
swissprot - D3YZY1
swissprot - D3YYJ6
Ensembl - ENSMUSG00000023088
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc1ENSDARG00000104719Danio rerio
 ABCC1ENSGALG00000006646Gallus gallus
 ABCC1ENSG00000103222Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcc3 / ATP binding cassette subfamily C member 3 / O15438*ENSMUSG0000002086556
Abcc2 / Q8VI47 / Canalicular multispecific organic anion transporter 1 / Q92887* / ATP binding cassette subfamily C member 2*ENSMUSG0000002519446
Abcc9 / P70170 / ATP-binding cassette, sub-family C (CFTR/MRP), member 9 / O60706* / ATP binding cassette subfamily C member 9*ENSMUSG0000003024932
Abcc4 / ATP-binding cassette, sub-family C (CFTR/MRP), member 4 / O15439* / ATP binding cassette subfamily C member 4*ENSMUSG0000003284931
Abcc12 / Q80WJ6 / Multidrug resistance-associated protein 9 / Q96J65* / ATP binding cassette subfamily C member 12*ENSMUSG0000003687230
Abcc5 / Q9R1X5 / Multidrug resistance-associated protein 5 / O15440* / ATP binding cassette subfamily C member 5*ENSMUSG0000002282230
Cftr / P26361 / Cystic fibrosis transmembrane conductance regulator / P13569*ENSMUSG0000004130122


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR005292  Multi drug resistance-associated protein
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IBA
 biological_processGO:0034775 glutathione transmembrane transport IBA
 biological_processGO:0042908 xenobiotic transport IBA
 biological_processGO:0045332 phospholipid translocation ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0099039 sphingolipid translocation ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004012 phospholipid-translocating ATPase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity IBA
 molecular_functionGO:0015431 glutathione S-conjugate-exporting ATPase activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity ISO
 molecular_functionGO:0022857 transmembrane transporter activity IEA
 molecular_functionGO:0034634 glutathione transmembrane transporter activity IBA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0046623 sphingolipid-translocating ATPase activity ISO


Pathways (from Reactome)
Pathway description
Cobalamin (Cbl, vitamin B12) transport and metabolism
Synthesis of Leukotrienes (LT) and Eoxins (EX)
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor,Tg(Thy1-AppDutch)#Jckr/0
Genetic Background: FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fancatm1Faw/Fanca+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fancatm1Faw/Fanca+
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor,Tg(Thy1-AppDutch)#Jckr/0
Genetic Background: FVB.Cg-Abcc1tm1Bor Tg(Thy1-AppDutch)#Jckr

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008918 microgliosis "a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcc1tm1Bor/Abcc1tm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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