ENSG00000125257


Homo sapiens

Features
Gene ID: ENSG00000125257
  
Biological name :ABCC4
  
Synonyms : ABCC4 / ATP binding cassette subfamily C member 4 / O15439
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q32.1
Gene start: 95019829
Gene end: 95301475
  
Corresponding Affymetrix probe sets: 1554918_a_at (Human Genome U133 Plus 2.0 Array)   1555039_a_at (Human Genome U133 Plus 2.0 Array)   203196_at (Human Genome U133 Plus 2.0 Array)   243928_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000495513
Ensembl peptide - ENSP00000366084
Ensembl peptide - ENSP00000442024
Ensembl peptide - ENSP00000487081
Ensembl peptide - ENSP00000494751
Ensembl peptide - ENSP00000494938
Ensembl peptide - ENSP00000493766
Ensembl peptide - ENSP00000493861
Ensembl peptide - ENSP00000494431
Ensembl peptide - ENSP00000494609
NCBI entrez gene - 10257     See in Manteia.
OMIM - 605250
RefSeq - XM_017020322
RefSeq - NM_001105515
RefSeq - NM_001301829
RefSeq - NM_001301830
RefSeq - NM_005845
RefSeq - XM_005254025
RefSeq - XM_017020319
RefSeq - XM_017020320
RefSeq - XM_017020321
RefSeq Peptide - NP_001098985
RefSeq Peptide - NP_001288758
RefSeq Peptide - NP_001288759
RefSeq Peptide - NP_005836
swissprot - Q8IWU1
swissprot - O15439
Ensembl - ENSG00000125257
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcc4ENSDARG00000058953Danio rerio
 ABCC4ENSGALG00000016896Gallus gallus
 Abcc4ENSMUSG00000032849Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCC1 / P33527 / ATP binding cassette subfamily C member 1ENSG0000010322237
ABCC2 / Q92887 / ATP binding cassette subfamily C member 2ENSG0000002383936
ABCC3 / O15438 / ATP binding cassette subfamily C member 3ENSG0000010884635
ABCC5 / O15440 / ATP binding cassette subfamily C member 5ENSG0000011477034
CFTR / P13569 / cystic fibrosis transmembrane conductance regulatorENSG0000000162634
ABCC12 / Q96J65 / ATP binding cassette subfamily C member 12ENSG0000014079833
ABCC9 / O60706 / ATP binding cassette subfamily C member 9ENSG0000006943131
ABCC8 / Q09428 / ATP binding cassette subfamily C member 8ENSG0000000607131
ABCC11 / Q96J66 / ATP binding cassette subfamily C member 11ENSG0000012127031


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030240  Multidrug resistance-associated protein 4
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0008150 biological_process ND
 biological_processGO:0010033 response to organic substance IEP
 biological_processGO:0010243 response to organonitrogen compound IEP
 biological_processGO:0014070 response to organic cyclic compound IEP
 biological_processGO:0032310 prostaglandin secretion IDA
 biological_processGO:0042493 response to drug IEP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0099131 ATP hydrolysis coupled ion transmembrane transport IEA
 biological_processGO:0099133 ATP hydrolysis coupled anion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0031088 platelet dense granule membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism TAS
 molecular_functionGO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity NAS
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0043225 ATPase-coupled anion transmembrane transporter activity TAS


Pathways (from Reactome)
Pathway description
Platelet degranulation
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr