ENSMUSG00000025197


Mus musculus

Features
Gene ID: ENSMUSG00000025197
  
Biological name :Cyp2c23
  
Synonyms : Cyp2c23 / cytochrome P450, family 2, subfamily c, polypeptide 23
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 44005022
Gene end: 44029208
  
Corresponding Affymetrix probe sets: 10467897 (MoGene1.0st)   1424576_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026211
Ensembl peptide - ENSMUSP00000148377
NCBI entrez gene - 226143     See in Manteia.
MGI - MGI:1888897
RefSeq - NM_001167905
RefSeq - NM_001001446
RefSeq - XM_017318162
RefSeq Peptide - NP_001001446
RefSeq Peptide - NP_001161377
swissprot - E9Q5K4
swissprot - A0A1D5RLI1
Ensembl - ENSMUSG00000025197
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 CYP2C23bENSGALG00000005795Gallus gallus
 CYP2C45ENSGALG00000023925Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp2c66 / cytochrome P450, family 2, subfamily c, polypeptide 66 / CYP2C9* / P33261* / P11712* / P10632* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P...ENSMUSG0000006722961
Cyp2c65 / cytochrome P450, family 2, subfamily c, polypeptide 65 / CYP2C9* / P33261* / P11712* / P10632* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P...ENSMUSG0000006723161
Q64458 / Cyp2c29 / Cytochrome P450 2C29 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000000305360
P56655 / Cyp2c38 / Cytochrome P450 2C38 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000003280859
Q91X77 / Cyp2c50 / Cytochrome P450 2C50 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000005482759
P56656 / Cyp2c39 / Cytochrome P450 2C39 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000002500359
P56654 / Cyp2c37 / Cytochrome P450 2C37 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000004224859
Q9D816 / Cyp2c55 / Cytochrome P450 2C55 / P33260* / CYP2C18* / AL583836.1* / cytochrome P450 family 2 subfamily C member 18*ENSMUSG0000002500258
Q6XVG2 / Cyp2c54 / Cytochrome P450 2C54 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000006722558
Cyp2e1 / Q05421 / Cytochrome P450 2E1 / P05181* / cytochrome P450 family 2 subfamily E member 1*ENSMUSG0000002547955
Q91W64 / Cyp2c70 / Cytochrome P450 2C70 ENSMUSG0000006061354
Cyp2c40 / CYP2C8* / CYP2C9* / P33261* / P11712* / P10632* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C member 8* / cytochrome P450 fami...ENSMUSG0000002500453
Cyp2g1 / cytochrome P450, family 2, subfamily g, polypeptide 1ENSMUSG0000004968551
P33267 / Cyp2f2 / Cytochrome P450 2F2 / CYP2F1* / P24903* / cytochrome P450 family 2 subfamily F member 1*ENSMUSG0000005297450
P15392 / Cyp2a4 / Cytochrome P450 2A4 / P11509* / Q16696* / P20853* / CYP2A7* / CYP2A6* / CYP2A13* / cytochrome P450 family 2 subfamily A member 7* / cytochrome P450 family 2 subfamily A m...ENSMUSG0000007425450
Cyp2a5 / CYP2A6* / CYP2A7* / Q16696* / P20853* / P11509* / CYP2A13* / cytochrome P450 family 2 subfamily A member 7* / cytochrome P450 family 2 subfamily A member 6* / cytochrome P450 famil...ENSMUSG0000000554750
Cyp2b10 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000003048349
Cyp2b23 / cytochrome P450, family 2, subfamily b, polypeptide 23 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004065049
Cyp2b9 / P12790 / Cytochrome P450 2B9 / P20813* / CYP2B6* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004066048
P56593 / Cyp2a12 / Cytochrome P450 2A12 ENSMUSG0000006040748


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008067  Cytochrome P450, E-class, group I, CYP2A-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0019373 epoxygenase P450 pathway IBA
 biological_processGO:0055114 oxidation-reduction process IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0002053 decreased incidence of induced tumors "reduced frequency of tumor incidence induced by a carcinogen or mutagen" [J:56886]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0002667 decreased circulating aldosterone level "decreased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

Allelic Composition: Cyp2c23tm1.1Jhc/Cyp2c23tm1.1Jhc,Tg(Hoxb7-cre)13Amc/0
Genetic Background: involves: C57BL/6

 MP:0011131 abnormal lung endothelial cell physiology "any functional anomaly of the squamous cells forming the lining of the pulmonary vasculature" [MGI:csmith]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

 MP:0011140 decreased lung endothelial cell proliferation "reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
Show

Allelic Composition: Kcnn2bc-7J/Kcnn2bc-7J
Genetic Background: B6.Cg-Kcnn2bc-7J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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