ENSMUSG00000025479


Mus musculus

Features
Gene ID: ENSMUSG00000025479
  
Biological name :Cyp2e1
  
Synonyms : Cyp2e1 / Cytochrome P450 2E1 / Q05421
  
Possible biological names infered from orthology : cytochrome P450 family 2 subfamily E member 1 / P05181
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F4
Gene start: 140763739
Gene end: 140774987
  
Corresponding Affymetrix probe sets: 10558673 (MoGene1.0st)   1415994_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148090
Ensembl peptide - ENSMUSP00000026552
Ensembl peptide - ENSMUSP00000147845
NCBI entrez gene - 13106     See in Manteia.
MGI - MGI:88607
RefSeq - NM_021282
RefSeq Peptide - NP_067257
swissprot - A0A1B0GSV7
swissprot - Q05421
swissprot - Q0PGA1
Ensembl - ENSMUSG00000025479
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 CYP2C23bENSGALG00000005795Gallus gallus
 CYP2C45ENSGALG00000023925Gallus gallus
 CYP2E1ENSG00000130649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cyp2c65 / cytochrome P450, family 2, subfamily c, polypeptide 65 / CYP2C9* / P33261* / P11712* / P10632* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P...ENSMUSG0000006723158
Cyp2c66 / cytochrome P450, family 2, subfamily c, polypeptide 66 / CYP2C9* / P33261* / P11712* / P10632* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P...ENSMUSG0000006722957
Cyp2c23 / cytochrome P450, family 2, subfamily c, polypeptide 23ENSMUSG0000002519755
P56655 / Cyp2c38 / Cytochrome P450 2C38 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000003280855
P56656 / Cyp2c39 / Cytochrome P450 2C39 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000002500355
Q91X77 / Cyp2c50 / Cytochrome P450 2C50 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000005482755
Q64458 / Cyp2c29 / Cytochrome P450 2C29 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000000305354
Q9D816 / Cyp2c55 / Cytochrome P450 2C55 / P33260* / CYP2C18* / AL583836.1* / cytochrome P450 family 2 subfamily C member 18*ENSMUSG0000002500254
P56654 / Cyp2c37 / Cytochrome P450 2C37 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000004224854
Q6XVG2 / Cyp2c54 / Cytochrome P450 2C54 / P10632* / CYP2C9* / P33261* / P11712* / CYP2C8* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C...ENSMUSG0000006722554
Cyp2c40 / CYP2C8* / CYP2C9* / P33261* / P11712* / P10632* / CYP2C19* / cytochrome P450 family 2 subfamily C member 9* / cytochrome P450 family 2 subfamily C member 8* / cytochrome P450 fami...ENSMUSG0000002500452
Q91W64 / Cyp2c70 / Cytochrome P450 2C70 ENSMUSG0000006061351
P15392 / Cyp2a4 / Cytochrome P450 2A4 / P11509* / Q16696* / P20853* / CYP2A7* / CYP2A6* / CYP2A13* / cytochrome P450 family 2 subfamily A member 7* / cytochrome P450 family 2 subfamily A m...ENSMUSG0000007425448
Cyp2b23 / cytochrome P450, family 2, subfamily b, polypeptide 23 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004065048
Cyp2g1 / cytochrome P450, family 2, subfamily g, polypeptide 1ENSMUSG0000004968547
P33267 / Cyp2f2 / Cytochrome P450 2F2 / CYP2F1* / P24903* / cytochrome P450 family 2 subfamily F member 1*ENSMUSG0000005297447
Cyp2a5 / CYP2A6* / CYP2A7* / Q16696* / P20853* / P11509* / CYP2A13* / cytochrome P450 family 2 subfamily A member 7* / cytochrome P450 family 2 subfamily A member 6* / cytochrome P450 famil...ENSMUSG0000000554747
Cyp2b10 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000003048346
Cyp2b13 / cytochrome P450, family 2, subfamily b, polypeptide 13 / CYP2B6* / P20813* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000004058345
O55071 / Cyp2b19 / Cytochrome P450 2B19 / P20813* / CYP2B6* / cytochrome P450 family 2 subfamily B member 6*ENSMUSG0000006670445


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008070  Cytochrome P450, E-class, group I, CYP2E-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0016098 monoterpenoid metabolic process IEA
 biological_processGO:0017144 drug metabolic process IEA
 biological_processGO:0019373 epoxygenase P450 pathway IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046483 heterocycle metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Xenobiotics
CYP2E1 reactions
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0004938 dilated vasculature "stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Nkx2-5tm1Krc/Nkx2-5tm1Krc
Genetic Background: either: (involves: 129/Sv * Black Swiss) or (involves: 129/Sv * C57BL/6)

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp2e1tm1Gonz/Cyp2e1tm1Gonz
Genetic Background: involves: 129S4/SvJae * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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