ENSG00000130649


Homo sapiens

Features
Gene ID: ENSG00000130649
  
Biological name :CYP2E1
  
Synonyms : CYP2E1 / cytochrome P450 family 2 subfamily E member 1 / P05181
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q26.3
Gene start: 133520406
Gene end: 133561220
  
Corresponding Affymetrix probe sets: 1431_at (Human Genome U133 Plus 2.0 Array)   209975_at (Human Genome U133 Plus 2.0 Array)   209976_s_at (Human Genome U133 Plus 2.0 Array)   222100_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000397299
Ensembl peptide - ENSP00000440689
Ensembl peptide - ENSP00000252945
Ensembl peptide - ENSP00000444958
Ensembl peptide - ENSP00000412754
Ensembl peptide - ENSP00000437799
NCBI entrez gene - 1571     See in Manteia.
OMIM - 124040
RefSeq - NM_000773
RefSeq Peptide - NP_000764
swissprot - H0Y7H4
swissprot - F5H694
swissprot - P05181
swissprot - H0YGV5
swissprot - H0Y593
Ensembl - ENSG00000130649
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 CYP2C23bENSGALG00000005795Gallus gallus
 CYP2C45ENSGALG00000023925Gallus gallus
 Cyp2e1ENSMUSG00000025479Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P33260 / CYP2C18 / cytochrome P450 family 2 subfamily C member 18ENSG0000010824257
P33261 / CYP2C19 / cytochrome P450 family 2 subfamily C member 19ENSG0000016584157
CYP2C9 / P11712 / cytochrome P450 family 2 subfamily C member 9ENSG0000013810957
CYP2C8 / P10632 / cytochrome P450 family 2 subfamily C member 8ENSG0000013811556
CYP2F1 / P24903 / cytochrome P450 family 2 subfamily F member 1ENSG0000019744648
Q16696 / CYP2A13 / cytochrome P450 family 2 subfamily A member 13ENSG0000019783847
CYP2A6 / P11509 / cytochrome P450 family 2 subfamily A member 6ENSG0000025597447
CYP2A7 / P20853 / cytochrome P450 family 2 subfamily A member 7ENSG0000019807746
CYP2B6 / P20813 / cytochrome P450 family 2 subfamily B member 6ENSG0000019740846
AL583836.1ENSG0000027649037


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR008070  Cytochrome P450, E-class, group I, CYP2E-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0016098 monoterpenoid metabolic process IDA
 biological_processGO:0017144 drug metabolic process TAS
 biological_processGO:0018885 carbon tetrachloride metabolic process TAS
 biological_processGO:0018910 benzene metabolic process TAS
 biological_processGO:0019373 epoxygenase P450 pathway IBA
 biological_processGO:0042197 halogenated hydrocarbon metabolic process TAS
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046483 heterocycle metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IDA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity TAS
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen TAS
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Xenobiotics
CYP2E1 reactions
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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