ENSG00000138115


Homo sapiens

Features
Gene ID: ENSG00000138115
  
Biological name :CYP2C8
  
Synonyms : CYP2C8 / cytochrome P450 family 2 subfamily C member 8 / P10632
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q23.33
Gene start: 95036772
Gene end: 95069497
  
Corresponding Affymetrix probe sets: 208147_s_at (Human Genome U133 Plus 2.0 Array)   219903_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433314
Ensembl peptide - ENSP00000487145
Ensembl peptide - ENSP00000485110
Ensembl peptide - ENSP00000445062
Ensembl peptide - ENSP00000442343
Ensembl peptide - ENSP00000433842
Ensembl peptide - ENSP00000360317
Ensembl peptide - ENSP00000433191
NCBI entrez gene - 1558     See in Manteia.
OMIM - 601129
RefSeq - NM_001198855
RefSeq - NM_000770
RefSeq - NM_001198853
RefSeq - NM_001198854
RefSeq Peptide - NP_000761
RefSeq Peptide - NP_001185782
RefSeq Peptide - NP_001185783
RefSeq Peptide - NP_001185784
swissprot - P10632
swissprot - E9PIW6
swissprot - B7Z1F5
swissprot - A0A0D9SG51
swissprot - G3V188
swissprot - E9PLI9
Ensembl - ENSG00000138115
  
Related genetic diseases (OMIM): 618018 - {Drug metabolism, altered, CYP2C8-related}, 618018
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 CYP2C23bENSGALG00000005795Gallus gallus
 CYP2C45ENSGALG00000023925Gallus gallus
 Cyp2c40ENSMUSG00000025004Mus musculus
 Cyp2c65ENSMUSG00000067231Mus musculus
 Cyp2c66ENSMUSG00000067229Mus musculus
 P56654ENSMUSG00000042248Mus musculus
 P56655ENSMUSG00000032808Mus musculus
 P56656ENSMUSG00000025003Mus musculus
 Q64458ENSMUSG00000003053Mus musculus
 Q6XVG2ENSMUSG00000067225Mus musculus
 Q91X77ENSMUSG00000054827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP2C9 / P11712 / cytochrome P450 family 2 subfamily C member 9ENSG0000013810978
P33261 / CYP2C19 / cytochrome P450 family 2 subfamily C member 19ENSG0000016584178
P33260 / CYP2C18 / cytochrome P450 family 2 subfamily C member 18ENSG0000010824277
CYP2E1 / P05181 / cytochrome P450 family 2 subfamily E member 1ENSG0000013064957
AL583836.1ENSG0000027649052
Q16696 / CYP2A13 / cytochrome P450 family 2 subfamily A member 13ENSG0000019783851
CYP2B6 / P20813 / cytochrome P450 family 2 subfamily B member 6ENSG0000019740850
CYP2F1 / P24903 / cytochrome P450 family 2 subfamily F member 1ENSG0000019744650
CYP2A7 / P20853 / cytochrome P450 family 2 subfamily A member 7ENSG0000019807749
CYP2A6 / P11509 / cytochrome P450 family 2 subfamily A member 6ENSG0000025597449


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002933 lipid hydroxylation IDA
 biological_processGO:0006082 organic acid metabolic process IDA
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IDA
 biological_processGO:0017144 drug metabolic process IDA
 biological_processGO:0019373 epoxygenase P450 pathway TAS
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0070989 oxidative demethylation IDA
 biological_processGO:0097267 omega-hydroxylase P450 pathway TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0034875 caffeine oxidase activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA
 molecular_functionGO:0101020 estrogen 16-alpha-hydroxylase activity IDA


Pathways (from Reactome)
Pathway description
Xenobiotics
CYP2E1 reactions
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)
Biosynthesis of maresin-like SPMs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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