ENSG00000165841


Homo sapiens

Features
Gene ID: ENSG00000165841
  
Biological name :CYP2C19
  
Synonyms : CYP2C19 / cytochrome P450 family 2 subfamily C member 19 / P33261
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q23.33
Gene start: 94762681
Gene end: 94853205
  
Corresponding Affymetrix probe sets: 216058_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000360372
Ensembl peptide - ENSP00000483847
NCBI entrez gene - 1557     See in Manteia.
OMIM - 124020
RefSeq - NM_000769
RefSeq Peptide - NP_000760
swissprot - A0A087X125
swissprot - P33261
Ensembl - ENSG00000165841
  
Related genetic diseases (OMIM): 609535 - Clopidogrel, impaired responsiveness to, 609535
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 CYP2C23bENSGALG00000005795Gallus gallus
 CYP2C45ENSGALG00000023925Gallus gallus
 Cyp2c40ENSMUSG00000025004Mus musculus
 Cyp2c65ENSMUSG00000067231Mus musculus
 Cyp2c66ENSMUSG00000067229Mus musculus
 P56654ENSMUSG00000042248Mus musculus
 P56655ENSMUSG00000032808Mus musculus
 P56656ENSMUSG00000025003Mus musculus
 Q64458ENSMUSG00000003053Mus musculus
 Q6XVG2ENSMUSG00000067225Mus musculus
 Q91X77ENSMUSG00000054827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYP2C9 / P11712 / cytochrome P450 family 2 subfamily C member 9ENSG0000013810991
P33260 / CYP2C18 / cytochrome P450 family 2 subfamily C member 18ENSG0000010824281
CYP2C8 / P10632 / cytochrome P450 family 2 subfamily C member 8ENSG0000013811578
CYP2E1 / P05181 / cytochrome P450 family 2 subfamily E member 1ENSG0000013064957
AL583836.1ENSG0000027649052
Q16696 / CYP2A13 / cytochrome P450 family 2 subfamily A member 13ENSG0000019783852
CYP2F1 / P24903 / cytochrome P450 family 2 subfamily F member 1ENSG0000019744651
CYP2A6 / P11509 / cytochrome P450 family 2 subfamily A member 6ENSG0000025597451
CYP2A7 / P20853 / cytochrome P450 family 2 subfamily A member 7ENSG0000019807750
CYP2B6 / P20813 / cytochrome P450 family 2 subfamily B member 6ENSG0000019740848


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0016098 monoterpenoid metabolic process IDA
 biological_processGO:0017144 drug metabolic process IDA
 biological_processGO:0019373 epoxygenase P450 pathway TAS
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0046483 heterocycle metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IDA
 biological_processGO:0097267 omega-hydroxylase P450 pathway TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle TAS
 molecular_functionGO:0004497 monooxygenase activity IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IMP
 molecular_functionGO:0016491 oxidoreductase activity IDA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0020037 heme binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Xenobiotics
CYP2E1 reactions
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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