ENSG00000197408


Homo sapiens

Features
Gene ID: ENSG00000197408
  
Biological name :CYP2B6
  
Synonyms : CYP2B6 / cytochrome P450 family 2 subfamily B member 6 / P20813
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 40991250
Gene end: 41018398
  
Corresponding Affymetrix probe sets: 206754_s_at (Human Genome U133 Plus 2.0 Array)   206755_at (Human Genome U133 Plus 2.0 Array)   217133_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000324648
Ensembl peptide - ENSP00000470582
Ensembl peptide - ENSP00000495579
Ensembl peptide - ENSP00000496294
NCBI entrez gene - 1555     See in Manteia.
OMIM - 123930
RefSeq - XM_011526550
RefSeq - NM_000767
RefSeq - XM_011526547
RefSeq - XM_011526548
RefSeq - XM_011526549
RefSeq - XM_005258569
RefSeq - XM_006723050
RefSeq - XM_011526546
RefSeq Peptide - NP_000758
swissprot - P20813
swissprot - M0QZJ2
Ensembl - ENSG00000197408
  
Related genetic diseases (OMIM): 614546 - Efavirenz, poor metabolism of, 614546
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CYP2C9ENSDARG00000101423Danio rerio
 Cyp2b10ENSMUSG00000030483Mus musculus
 Cyp2b13ENSMUSG00000040583Mus musculus
 Cyp2b23ENSMUSG00000040650Mus musculus
 Cyp2b9ENSMUSG00000040660Mus musculus
 O55071ENSMUSG00000066704Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q16696 / CYP2A13 / cytochrome P450 family 2 subfamily A member 13ENSG0000019783853
CYP2A6 / P11509 / cytochrome P450 family 2 subfamily A member 6ENSG0000025597451
CYP2A7 / P20853 / cytochrome P450 family 2 subfamily A member 7ENSG0000019807751
CYP2C8 / P10632 / cytochrome P450 family 2 subfamily C member 8ENSG0000013811550
P33261 / CYP2C19 / cytochrome P450 family 2 subfamily C member 19ENSG0000016584148
CYP2F1 / P24903 / cytochrome P450 family 2 subfamily F member 1ENSG0000019744648
CYP2C9 / P11712 / cytochrome P450 family 2 subfamily C member 9ENSG0000013810948
P33260 / CYP2C18 / cytochrome P450 family 2 subfamily C member 18ENSG0000010824247
CYP2E1 / P05181 / cytochrome P450 family 2 subfamily E member 1ENSG0000013064946
AL583836.1ENSG0000027649030


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR002403  Cytochrome P450, E-class, group IV
 IPR008068  Cytochrome P450, E-class, group I, CYP2B-like
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IMP
 biological_processGO:0017144 drug metabolic process IMP
 biological_processGO:0019373 epoxygenase P450 pathway IBA
 biological_processGO:0042180 cellular ketone metabolic process IDA
 biological_processGO:0042738 exogenous drug catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008392 arachidonic acid epoxygenase activity IBA
 molecular_functionGO:0008395 steroid hydroxylase activity IBA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
 molecular_functionGO:0019825 oxygen binding TAS
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Fatty acids
Xenobiotics
CYP2E1 reactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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