ENSMUSG00000025337


Mus musculus

Features
Gene ID: ENSMUSG00000025337
  
Biological name :Sbds
  
Synonyms : P70122 / Ribosome maturation protein SBDS / Sbds
  
Possible biological names infered from orthology : Q9Y3A5 / SBDS, ribosome maturation factor
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G1.3
Gene start: 130245731
Gene end: 130255530
  
Corresponding Affymetrix probe sets: 10534142 (MoGene1.0st)   1426480_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026387
Ensembl peptide - ENSMUSP00000115494
Ensembl peptide - ENSMUSP00000117348
NCBI entrez gene - 66711     See in Manteia.
MGI - MGI:1913961
RefSeq - XM_006504490
RefSeq - NM_023248
RefSeq Peptide - NP_075737
swissprot - D6REV5
swissprot - P70122
swissprot - F6TN03
Ensembl - ENSMUSG00000025337
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sbdsENSDARG00000027803Danio rerio
 SBDSENSGALG00000027989Gallus gallus
 SBDSENSG00000126524Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002140  Ribosome maturation protein Sdo1/SBDS
 IPR018023  Ribosome maturation protein SBDS, conserved site
 IPR018978  Ribosome maturation protein SBDS, C-terminal
 IPR019783  Ribosome maturation protein SBDS, N-terminal
 IPR036786  Ribosome maturation protein SBDS, N-terminal domain superfamily
 IPR037188  Ribosome maturation protein Sdo1/SBDS, central domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001833 inner cell mass cell proliferation IMP
 biological_processGO:0006364 rRNA processing IEA
 biological_processGO:0007052 mitotic spindle organization IEA
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0030282 bone mineralization IEA
 biological_processGO:0030595 leukocyte chemotaxis IEA
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042256 mature ribosome assembly IEA
 biological_processGO:0048539 bone marrow development IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0019843 rRNA binding IEA
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0003338 pancreatic lipomatosis "an accumulation of abnormally localized or tumor-like fat in the pancreas" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0008250 abnormal myeloid leukocyte morphology "any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage" [CL:0000766]
Show

Allelic Composition: Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc,Tg(Krt1-5-cre/ERT)1Ipc/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0009154 pancreatic acinar hypoplasia "underdevelopment or reduced size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to a decreased cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009170 abnormal pancreatic islet size "anomaly in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Adora1tm1Bbf/Adora1tm1Bbf
Genetic Background: B6.129P2-Adora1tm1Bbf

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0012114 absent inner cell mass proliferation 
Show

Allelic Composition: Gja5tm1Paul/Gja5+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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