ENSMUSG00000025742


Mus musculus

Features
Gene ID: ENSMUSG00000025742
  
Biological name :Prps2
  
Synonyms : Prps2 / Q9CS42 / Ribose-phosphate pyrophosphokinase 2
  
Possible biological names infered from orthology : P11908 / phosphoribosyl pyrophosphate synthetase 2
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F5
Gene start: 167346322
Gene end: 167382749
  
Corresponding Affymetrix probe sets: 10607877 (MoGene1.0st)   1420637_at (Mouse Genome 430 2.0 Array)   1420638_at (Mouse Genome 430 2.0 Array)   1454843_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026839
NCBI entrez gene - 110639     See in Manteia.
MGI - MGI:97776
RefSeq - NM_026662
RefSeq - NM_001313758
RefSeq Peptide - NP_001300687
RefSeq Peptide - NP_080938
swissprot - Q9CS42
Ensembl - ENSMUSG00000025742
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRPS2ENSGALG00000016592Gallus gallus
 PRPS2ENSG00000101911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prps1l3 / PRPS1* / P60891* / phosphoribosyl pyrophosphate synthetase 1*ENSMUSG0000007910495
Prps1 / Q9D7G0 / Ribose-phosphate pyrophosphokinase 1 / P21108* / PRPS1L1* / phosphoribosyl pyrophosphate synthetase 1-like 1*ENSMUSG0000003143295
Prps1l1 / phosphoribosyl pyrophosphate synthetase 1-like 1ENSMUSG0000009230591
Q8R574 / Prpsap2 / phosphoribosyl pyrophosphate synthetase-associated protein 2 / O60256*ENSMUSG0000002052848
Prpsap1 / phosphoribosyl pyrophosphate synthetase-associated protein 1 / Q14558*ENSMUSG0000001586946


Protein motifs (from Interpro)
Interpro ID Name
 IPR000836  Phosphoribosyltransferase domain
 IPR000842  Phosphoribosyl pyrophosphate synthetase, conserved site
 IPR005946  Ribose-phosphate pyrophosphokinase
 IPR029057  Phosphoribosyltransferase-like
 IPR029099  Ribose-phosphate pyrophosphokinase, N-terminal domain
 IPR037515  Ribose-phosphate pyrophosphokinase, bacterial-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEA
 biological_processGO:0006167 AMP biosynthetic process IEA
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019693 ribose phosphate metabolic process IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0044249 cellular biosynthetic process IEA
 cellular_componentGO:0002189 ribose phosphate diphosphokinase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004749 ribose phosphate diphosphokinase activity ISS
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016208 AMP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
5-Phosphoribose 1-diphosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox10gt/Sox10tm1Weg
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * GT/Le

Allelic Composition: Prps2tm1a(KOMP)Wtsi/Y,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6N * SJL

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prps2tm1a(KOMP)Wtsi/Y,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6N * SJL

 MP:0009828 delayed tumor appearance "later onset of tumor occurence than expected, but with expected incidence" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Prps2tm1a(KOMP)Wtsi/Y,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6N * SJL

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prps2tm1a(KOMP)Wtsi/Y,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025742 Prps2 / Q9CS42 / Ribose-phosphate pyrophosphokinase 2 / P11908* / phosphoribosyl pyrophosphate synthetase 2*  / complex






 

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