ENSG00000101911


Homo sapiens

Features
Gene ID: ENSG00000101911
  
Biological name :PRPS2
  
Synonyms : P11908 / phosphoribosyl pyrophosphate synthetase 2 / PRPS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 12791355
Gene end: 12824222
  
Corresponding Affymetrix probe sets: 203401_at (Human Genome U133 Plus 2.0 Array)   230352_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370043
Ensembl peptide - ENSP00000419380
Ensembl peptide - ENSP00000418911
Ensembl peptide - ENSP00000381504
Ensembl peptide - ENSP00000370038
NCBI entrez gene - 5634     See in Manteia.
OMIM - 311860
RefSeq - NM_002765
RefSeq - NM_001039091
RefSeq Peptide - NP_001034180
RefSeq Peptide - NP_002756
swissprot - D3YTJ7
swissprot - P11908
swissprot - A6NMS2
swissprot - A0A140VK41
swissprot - H7C540
Ensembl - ENSG00000101911
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PRPS2ENSGALG00000016592Gallus gallus
 Prps2ENSMUSG00000025742Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRPS1 / P60891 / phosphoribosyl pyrophosphate synthetase 1ENSG0000014722494
P21108 / PRPS1L1 / phosphoribosyl pyrophosphate synthetase 1-like 1ENSG0000022993789
O60256 / PRPSAP2 / phosphoribosyl pyrophosphate synthetase associated protein 2ENSG0000014112747
Q14558 / PRPSAP1 / phosphoribosyl pyrophosphate synthetase associated protein 1ENSG0000016154245


Protein motifs (from Interpro)
Interpro ID Name
 IPR000836  Phosphoribosyltransferase domain
 IPR000842  Phosphoribosyl pyrophosphate synthetase, conserved site
 IPR005946  Ribose-phosphate pyrophosphokinase
 IPR029057  Phosphoribosyltransferase-like
 IPR029099  Ribose-phosphate pyrophosphokinase, N-terminal domain
 IPR037515  Ribose-phosphate pyrophosphokinase, bacterial-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEA
 biological_processGO:0006139 nucleobase-containing compound metabolic process TAS
 biological_processGO:0006167 AMP biosynthetic process IEA
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019693 ribose phosphate metabolic process IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0044249 cellular biosynthetic process IEA
 cellular_componentGO:0002189 ribose phosphate diphosphokinase complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004749 ribose phosphate diphosphokinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISS
 molecular_functionGO:0016208 AMP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
5-Phosphoribose 1-diphosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000101911 PRPS2 / P11908 / phosphoribosyl pyrophosphate synthetase 2  / complex






 

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