ENSMUSG00000031432


Mus musculus

Features
Gene ID: ENSMUSG00000031432
  
Biological name :Prps1
  
Synonyms : Prps1 / Q9D7G0 / Ribose-phosphate pyrophosphokinase 1
  
Possible biological names infered from orthology : P21108 / phosphoribosyl pyrophosphate synthetase 1-like 1 / PRPS1L1
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: F1
Gene start: 140456613
Gene end: 140476140
  
Corresponding Affymetrix probe sets: 10602062 (MoGene1.0st)   1416052_at (Mouse Genome 430 2.0 Array)   1448192_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033809
NCBI entrez gene - 19139     See in Manteia.
MGI - MGI:97775
RefSeq - NM_021463
RefSeq Peptide - NP_067438
swissprot - Q9D7G0
Ensembl - ENSMUSG00000031432
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prps1aENSDARG00000015524Danio rerio
 prps1bENSDARG00000037506Danio rerio
 ENSGALG00000004908Gallus gallus
 P21108ENSG00000229937Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prps1l3 / PRPS1* / P60891* / phosphoribosyl pyrophosphate synthetase 1*ENSMUSG00000079104100
Prps1l1 / phosphoribosyl pyrophosphate synthetase 1-like 1ENSMUSG0000009230595
Prps2 / Q9CS42 / Ribose-phosphate pyrophosphokinase 2 / P11908* / phosphoribosyl pyrophosphate synthetase 2*ENSMUSG0000002574295
Q8R574 / Prpsap2 / phosphoribosyl pyrophosphate synthetase-associated protein 2 / O60256*ENSMUSG0000002052847
Prpsap1 / phosphoribosyl pyrophosphate synthetase-associated protein 1 / Q14558*ENSMUSG0000001586945


Protein motifs (from Interpro)
Interpro ID Name
 IPR000836  Phosphoribosyltransferase domain
 IPR000842  Phosphoribosyl pyrophosphate synthetase, conserved site
 IPR005946  Ribose-phosphate pyrophosphokinase
 IPR029057  Phosphoribosyltransferase-like
 IPR029099  Ribose-phosphate pyrophosphokinase, N-terminal domain
 IPR037515  Ribose-phosphate pyrophosphokinase, bacterial-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006015 5-phosphoribose 1-diphosphate biosynthetic process IEA
 biological_processGO:0006144 purine nucleobase metabolic process ISO
 biological_processGO:0006164 purine nucleotide biosynthetic process ISO
 biological_processGO:0007399 nervous system development ISO
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034418 urate biosynthetic process ISO
 biological_processGO:0044249 cellular biosynthetic process IEA
 biological_processGO:0046101 hypoxanthine biosynthetic process ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004749 ribose phosphate diphosphokinase activity ISO
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
5-Phosphoribose 1-diphosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002699 abnormal vitreous body "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prpf31tm1a(EUCOMM)Wtsi/Prpf31tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Prpf31tm1a(EUCOMM)Wtsi/Nju

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Prkab1tm1b(KOMP)Wtsi/Orl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031432 Prps1 / Q9D7G0 / Ribose-phosphate pyrophosphokinase 1 / P21108* / PRPS1L1* / phosphoribosyl pyrophosphate synthetase 1-like 1*  / complex






 

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