ENSDARG00000015524


Danio rerio

Features
Gene ID: ENSDARG00000015524
  
Biological name :prps1a
  
Synonyms : phosphoribosyl pyrophosphate synthetase 1A / prps1a
  
Possible biological names infered from orthology : P21108 / P60891 / phosphoribosyl pyrophosphate synthetase 1 / phosphoribosyl pyrophosphate synthetase 1-like 1 / PRPS1 / PRPS1L1 / Prps1l3 / Q9D7G0 / Ribose-phosphate pyrophosphokinase 1
  
Species: Danio rerio
  
Chr. number: 5
Strand: 1
Band:
Gene start: 23136544
Gene end: 23147665
  
Corresponding Affymetrix probe sets: Dr.2896.1.S1_at (Zebrafish Array)   NM_213533_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000097681
Ensembl peptide - ENSDARP00000144425
Ensembl peptide - ENSDARP00000140447
Ensembl peptide - ENSDARP00000008663
NCBI entrez gene - 140620     See in Manteia.
RefSeq - XM_009301279
RefSeq - XM_005165092
RefSeq - NM_213327
RefSeq - NM_213533
RefSeq - XM_009301280
RefSeq Peptide - NP_998492
RefSeq Peptide - NP_998698
swissprot - Q6NYR9
swissprot - Q7ZW39
swissprot - Q4KME9
swissprot - A3KQE8
swissprot - A0A0R4IW25
ZFIN ID - ZDB-GENE-011212-5
Ensembl - ENSDARG00000015524
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000004908Gallus gallus
 P21108ENSG00000229937Homo sapiens
 PRPS1ENSG00000147224Homo sapiens
 Prps1ENSMUSG00000031432Mus musculus
 Prps1l1ENSMUSG00000092305Mus musculus
 Prps1l3ENSMUSG00000079104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prps1b / phosphoribosyl pyrophosphate synthetase 1B / PRPS1* / Q9D7G0* / P60891* / P21108* / Prps1l3* / PRPS1L1* / Ribose-phosphate pyrophosphokinase 1 * / phosphoribosyl pyrophosphate synt...ENSDARG0000003750696
prpsap2 / phosphoribosyl pyrophosphate synthetase-associated protein 2 / O60256* / Q8R574*ENSDARG0000001932647
prpsap1 / phosphoribosyl pyrophosphate synthetase-associated protein 1 / Q14558*ENSDARG0000009922219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000836  Phosphoribosyltransferase domain
 IPR000842  Phosphoribosyl pyrophosphate synthetase, conserved site
 IPR005946  Ribose-phosphate pyrophosphokinase
 IPR029057  Phosphoribosyltransferase-like
 IPR029099  Ribose-phosphate pyrophosphokinase, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0044249 cellular biosynthetic process IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004749 ribose phosphate diphosphokinase activity IEA


Pathways (from Reactome)
Pathway description
5-Phosphoribose 1-diphosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium decreased thickness , abnormal
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 ZFA:0000152 retina retina proliferative region increased amount , abnormal
retina proliferative region mislocalised , abnormal
retina cell decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0009199 iridophore iridophore decreased amount , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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