ENSDARG00000037506


Danio rerio

Features
Gene ID: ENSDARG00000037506
  
Biological name :prps1b
  
Synonyms : phosphoribosyl pyrophosphate synthetase 1B / prps1b
  
Possible biological names infered from orthology : P21108 / P60891 / phosphoribosyl pyrophosphate synthetase 1 / phosphoribosyl pyrophosphate synthetase 1-like 1 / PRPS1 / PRPS1L1 / Prps1l3 / Q9D7G0 / Ribose-phosphate pyrophosphokinase 1
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 12076821
Gene end: 12106603
  
Corresponding Affymetrix probe sets: Dr.7674.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000054618
NCBI entrez gene - 560827     See in Manteia.
RefSeq - NM_001076568
RefSeq Peptide - NP_001070036
swissprot - Q08CA5
ZFIN ID - ZDB-GENE-030131-4011
Ensembl - ENSDARG00000037506
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000004908Gallus gallus
 P21108ENSG00000229937Homo sapiens
 PRPS1ENSG00000147224Homo sapiens
 Prps1ENSMUSG00000031432Mus musculus
 Prps1l1ENSMUSG00000092305Mus musculus
 Prps1l3ENSMUSG00000079104Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
prps1a / phosphoribosyl pyrophosphate synthetase 1A / PRPS1* / Q9D7G0* / P60891* / P21108* / Prps1l3* / PRPS1L1* / Ribose-phosphate pyrophosphokinase 1 * / phosphoribosyl pyrophosphate synt...ENSDARG0000001552497
prpsap2 / phosphoribosyl pyrophosphate synthetase-associated protein 2 / O60256* / Q8R574*ENSDARG0000001932647
prpsap1 / phosphoribosyl pyrophosphate synthetase-associated protein 1 / Q14558*ENSDARG0000009922219


Protein motifs (from Interpro)
Interpro ID Name
 IPR000836  Phosphoribosyltransferase domain
 IPR000842  Phosphoribosyl pyrophosphate synthetase, conserved site
 IPR005946  Ribose-phosphate pyrophosphokinase
 IPR029057  Phosphoribosyltransferase-like
 IPR029099  Ribose-phosphate pyrophosphokinase, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009116 nucleoside metabolic process IEA
 biological_processGO:0009156 ribonucleoside monophosphate biosynthetic process IEA
 biological_processGO:0009165 nucleotide biosynthetic process IEA
 biological_processGO:0044249 cellular biosynthetic process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004749 ribose phosphate diphosphokinase activity IEA


Pathways (from Reactome)
Pathway description
5-Phosphoribose 1-diphosphate biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000046 retinal neural layer retinal neural layer disorganized , abnormal
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 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
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 ZFA:0000084 yolk yolk iridophore decreased amount , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye decreased pigmentation , abnormal
eye decreased size , exacerbated
eye iridophore decreased amount , abnormal
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 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium hypoplastic , abnormal
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 ZFA:0000217 inner ear inner ear hair cell decreased amount , abnormal
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 ZFA:0000435 cranial nerve II cranial nerve II decreased thickness , abnormal
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 ZFA:0001094 whole organism whole organism 5-O-phosphono-alpha-D-ribofuranosyl diphosphate decreased amount , abnormal
whole organism IMP decreased amount , abnormal
whole organism uric acid decreased amount , abnormal
whole organism decreased size , exacerbated
whole organism decreased life span , abnormal
whole organism decreased amount , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage structure , exacerbated
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 ZFA:0009141 macrophage macrophage decreased amount , abnormal
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 ZFA:0009238 afferent neuron afferent neuron morphology , abnormal
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 ZFA:0009244 primary motor neuron primary motor neuron axon decreased length , abnormal
primary motor neuron axon increased branchiness , abnormal
primary motor neuron pseudopodium increased amount , abnormal
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 ZFA:0009327 neutrophil neutrophil decreased amount , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell synapse increased amount , abnormal
neuromast hair cell cytoskeleton of presynaptic active zone increased amount , abnormal
neuromast hair cell innervation process quality , abnormal
neuromast hair cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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