ENSMUSG00000025980


Mus musculus

Features
Gene ID: ENSMUSG00000025980
  
Biological name :Hspd1
  
Synonyms : heat shock protein 1 (chaperonin) / Hspd1 / P63038
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C1.2
Gene start: 55077835
Gene end: 55088243
  
Corresponding Affymetrix probe sets: 10354732 (MoGene1.0st)   10375240 (MoGene1.0st)   1426351_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000119336
Ensembl peptide - ENSMUSP00000122947
Ensembl peptide - ENSMUSP00000027123
NCBI entrez gene - 15510     See in Manteia.
MGI - MGI:96242
RefSeq - NM_010477
RefSeq - XM_006495706
RefSeq Peptide - NP_001343441
RefSeq Peptide - NP_034607
swissprot - D3Z2F2
swissprot - P63038
swissprot - D3Z7J9
Ensembl - ENSMUSG00000025980
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hspd1ENSDARG00000056160Danio rerio
 HSPD1ENSGALG00000008094Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001844  Chaperonin Cpn60
 IPR002423  Chaperonin Cpn60/TCP-1 family
 IPR017998  Chaperone tailless complex polypeptide 1 (TCP-1)
 IPR018370  Chaperonin Cpn60, conserved site
 IPR027409  GroEL-like apical domain superfamily
 IPR027410  TCP-1-like chaperonin intermediate domain superfamily
 IPR027413  GroEL-like equatorial domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0002368 B cell cytokine production ISO
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway ISO
 biological_processGO:0002842 positive regulation of T cell mediated immune response to tumor cell ISO
 biological_processGO:0002931 response to ischemia IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006458 "de novo" protein folding IBA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
 biological_processGO:0006986 response to unfolded protein ISO
 biological_processGO:0008637 apoptotic mitochondrial changes IEA
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009409 response to cold ISS
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production ISO
 biological_processGO:0032729 positive regulation of interferon-gamma production ISO
 biological_processGO:0032733 positive regulation of interleukin-10 production ISO
 biological_processGO:0032735 positive regulation of interleukin-12 production ISO
 biological_processGO:0032755 positive regulation of interleukin-6 production ISO
 biological_processGO:0033198 response to ATP IEA
 biological_processGO:0034605 cellular response to heat IEA
 biological_processGO:0042026 protein refolding ISO
 biological_processGO:0042100 B cell proliferation ISO
 biological_processGO:0042110 T cell activation ISO
 biological_processGO:0042113 B cell activation ISO
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0043032 positive regulation of macrophage activation ISO
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045041 protein import into mitochondrial intermembrane space IBA
 biological_processGO:0048291 isotype switching to IgG isotypes ISO
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0050870 positive regulation of T cell activation ISO
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051702 interaction with symbiont ISO
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0071866 negative regulation of apoptotic process in bone marrow IEA
 biological_processGO:1903427 negative regulation of reactive oxygen species biosynthetic process IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005769 early endosome ISO
 cellular_componentGO:0005782 peroxisomal matrix IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005905 clathrin-coated pit ISO
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IMP
 cellular_componentGO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex ISO
 cellular_componentGO:0030061 mitochondrial crista IEA
 cellular_componentGO:0030135 coated vesicle ISO
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032991 protein-containing complex ISS
 cellular_componentGO:0042588 zymogen granule IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0046696 lipopolysaccharide receptor complex ISO
 cellular_componentGO:0070062 extracellular exosome ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003725 double-stranded RNA binding ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008035 high-density lipoprotein particle binding ISO
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0034185 apolipoprotein binding ISO
 molecular_functionGO:0034186 apolipoprotein A-I binding ISO
 molecular_functionGO:0043559 insulin binding IEA
 molecular_functionGO:0044183 protein binding involved in protein folding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0051082 unfolded protein binding IBA
 molecular_functionGO:0051087 chaperone binding ISO
 molecular_functionGO:0140030 modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0011105 partial embryonic lethality between implantation and placentation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ern1tm1Rjk/Ern1tm2.1Rjk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0011636 disorganized mitochondrial cristae "derangement of the pattern of the inward folds of the mitochondrial inner membrane" [MGI:csmith]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

 MP:0012051 spasticity "a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes and increased resistance to stretch" [HP:0001257, MGI:csmith]
Show

Allelic Composition: Slc6a2tm1.1Mkh/Slc6a2+
Genetic Background: B6.129S6-Slc6a2tm1.1Mkh

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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