ENSMUSG00000026358


Mus musculus

Features
Gene ID: ENSMUSG00000026358
  
Biological name :Rgs1
  
Synonyms : Q9JL25 / regulator of G-protein signaling 1 / Rgs1
  
Possible biological names infered from orthology : Q08116
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: F
Gene start: 144242296
Gene end: 144249242
  
Corresponding Affymetrix probe sets: 10358408 (MoGene1.0st)   1417601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000130339
Ensembl peptide - ENSMUSP00000140902
Ensembl peptide - ENSMUSP00000140624
Ensembl peptide - ENSMUSP00000140300
Ensembl peptide - ENSMUSP00000139778
Ensembl peptide - ENSMUSP00000126270
NCBI entrez gene - 50778     See in Manteia.
MGI - MGI:1354694
RefSeq - NM_015811
RefSeq Peptide - NP_056626
swissprot - A0A087WQQ4
swissprot - E9PZR4
swissprot - Q9JL25
swissprot - A0A0A0MQN0
swissprot - A0A087WS51
Ensembl - ENSMUSG00000026358
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RGS1ENSGALG00000002549Gallus gallus
 RGS1ENSG00000090104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG0000002636037
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853036
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667836
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850936
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG0000002635736
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981035
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267133
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG0000002647532
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG0000005107931
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245830
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245928
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977527


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR030409  Regulator of G-protein signalling 1
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0061737 leukotriene signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Krt71Cal4/?
Genetic Background: C57BL/6J-Krt71Cal4/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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