ENSMUSG00000026678


Mus musculus

Features
Gene ID: ENSMUSG00000026678
  
Biological name :Rgs5
  
Synonyms : O08850 / regulator of G-protein signaling 5 / Rgs5
  
Possible biological names infered from orthology : O15539
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.3
Gene start: 169655501
Gene end: 169695813
  
Corresponding Affymetrix probe sets: 10351455 (MoGene1.0st)   10351463 (MoGene1.0st)   1417466_at (Mouse Genome 430 2.0 Array)   1420940_x_at (Mouse Genome 430 2.0 Array)   1420941_at (Mouse Genome 430 2.0 Array)   1420942_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027997
Ensembl peptide - ENSMUSP00000141496
NCBI entrez gene - 19737     See in Manteia.
MGI - MGI:1098434
RefSeq - NM_001313705
RefSeq - NM_009063
RefSeq Peptide - NP_001300634
RefSeq Peptide - NP_033089
swissprot - O08850
swissprot - A0A0A6YWD0
Ensembl - ENSMUSG00000026678
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs5aENSDARG00000002644Danio rerio
 RGS5ENSGALG00000026572Gallus gallus
 RGS5ENSG00000143248Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853052
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981051
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG0000002647550
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG0000002635746
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG0000002636045
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267145
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG0000002635842
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850939
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245936
Rgs13 / Q8K443 / Regulator of G-protein signaling 13 / O14921*ENSMUSG0000005107935
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245834
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977533


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034955  Regulator of G-protein signalling 5
 IPR034956  Regulator of G-protein signalling 5, RGS domain
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005096 GTPase activator activity TAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0002009 preneoplasia "state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development" [J:47225]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lats2tm1Dgen/Lats2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0002626 increased heart rate "greater than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003364 insulinoma "a pancreatic islet beta cell adenoma that secretes excess insulin" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0003721 increased tumor growth/size "greater than expected development of tumorous growth when compared to controls" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rgs5tm1.1Rgan/Rgs5tm1.1Rgan
Genetic Background: involves: 129 * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Glis2tm1Amj/Glis2tm1Amj
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pou3f2tm1Tno/Pou3f2tm1Tno,Pou3f3tm1Tno/Pou3f3tm1Tno
Genetic Background: involves: 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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