ENSG00000143248


Homo sapiens

Features
Gene ID: ENSG00000143248
  
Biological name :RGS5
  
Synonyms : O15539 / regulator of G protein signaling 5 / RGS5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q23.3
Gene start: 163111121
Gene end: 163321791
  
Corresponding Affymetrix probe sets: 1555725_a_at (Human Genome U133 Plus 2.0 Array)   209070_s_at (Human Genome U133 Plus 2.0 Array)   209071_s_at (Human Genome U133 Plus 2.0 Array)   218353_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435861
Ensembl peptide - ENSP00000356879
Ensembl peptide - ENSP00000480891
Ensembl peptide - ENSP00000432313
Ensembl peptide - ENSP00000433001
Ensembl peptide - ENSP00000319308
NCBI entrez gene - 8490     See in Manteia.
OMIM - 603276
RefSeq - NM_001254748
RefSeq - NM_001254749
RefSeq - NM_003617
RefSeq - NM_001195303
RefSeq Peptide - NP_001182232
RefSeq Peptide - NP_001241678
RefSeq Peptide - NP_003608
RefSeq Peptide - NP_001241677
swissprot - O15539
swissprot - B1APM2
swissprot - A0A024R8X9
swissprot - E9PS96
Ensembl - ENSG00000143248
  
Related genetic diseases (OMIM): 145500 - [Blood pressure regulation QTL], 145500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs5aENSDARG00000002644Danio rerio
 RGS5ENSGALG00000026572Gallus gallus
 Rgs5ENSMUSG00000026678Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RGS4 / P49798 / regulator of G protein signaling 4ENSG0000011715251
RGS3 / P49796 / regulator of G protein signaling 3ENSG0000013883550
RGS16 / O15492 / regulator of G protein signaling 16ENSG0000014333350
RGS8 / P57771 / regulator of G protein signaling 8ENSG0000013582446
RGS2 / P41220 / regulator of G protein signaling 2ENSG0000011674145
RGS18 / Q9NS28 / regulator of G protein signaling 18ENSG0000015068145
RGS1 / Q08116 / regulator of G protein signaling 1ENSG0000009010439
RGS21 / Q2M5E4 / regulator of G protein signaling 21ENSG0000025314839
RGS20 / O76081 / regulator of G protein signaling 20ENSG0000014750934
RGS13 / O14921 / regulator of G protein signaling 13ENSG0000012707433
RGS19 / P49795 / regulator of G protein signaling 19ENSG0000017170031
RGS17 / Q9UGC6 / regulator of G protein signaling 17ENSG0000009184430


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034955  Regulator of G-protein signalling 5
 IPR034956  Regulator of G-protein signalling 5, RGS domain
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway TAS
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005096 GTPase activator activity TAS


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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