ENSG00000116741


Homo sapiens

Features
Gene ID: ENSG00000116741
  
Biological name :RGS2
  
Synonyms : P41220 / regulator of G protein signaling 2 / RGS2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q31.2
Gene start: 192809039
Gene end: 192812283
  
Corresponding Affymetrix probe sets: 202388_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000235382
NCBI entrez gene - 5997     See in Manteia.
OMIM - 600861
RefSeq - NM_002923
RefSeq Peptide - NP_002914
swissprot - A0A024R939
swissprot - P41220
Ensembl - ENSG00000116741
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs2ENSDARG00000098761Danio rerio
 RGS2ENSGALG00000042744Gallus gallus
 Rgs2ENSMUSG00000026360Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RGS3 / P49796 / regulator of G protein signaling 3ENSG0000013883542
RGS18 / Q9NS28 / regulator of G protein signaling 18ENSG0000015068141
RGS16 / O15492 / regulator of G protein signaling 16ENSG0000014333340
RGS4 / P49798 / regulator of G protein signaling 4ENSG0000011715239
RGS5 / O15539 / regulator of G protein signaling 5ENSG0000014324839
RGS8 / P57771 / regulator of G protein signaling 8ENSG0000013582438
RGS21 / Q2M5E4 / regulator of G protein signaling 21ENSG0000025314838
RGS1 / Q08116 / regulator of G protein signaling 1ENSG0000009010436
RGS13 / O14921 / regulator of G protein signaling 13ENSG0000012707431
RGS19 / P49795 / regulator of G protein signaling 19ENSG0000017170029
RGS20 / O76081 / regulator of G protein signaling 20ENSG0000014750927
RGS17 / Q9UGC6 / regulator of G protein signaling 17ENSG0000009184425


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034947  Regulator of G-protein signalling 2
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0008277 regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010519 negative regulation of phospholipase activity ISS
 biological_processGO:0010614 negative regulation of cardiac muscle hypertrophy ISS
 biological_processGO:0031116 positive regulation of microtubule polymerization IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity ISS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043951 negative regulation of cAMP-mediated signaling IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway ISS
 biological_processGO:0050873 brown fat cell differentiation IEA
 biological_processGO:0055119 relaxation of cardiac muscle ISS
 biological_processGO:0060087 relaxation of vascular smooth muscle IEA
 biological_processGO:0060452 positive regulation of cardiac muscle contraction ISS
 biological_processGO:0140194 negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process ISS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009898 cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0001965 G-protein alpha-subunit binding IPI
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding TAS
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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