ENSMUSG00000051079


Mus musculus

Features
Gene ID: ENSMUSG00000051079
  
Biological name :Rgs13
  
Synonyms : Q8K443 / Regulator of G-protein signaling 13 / Rgs13
  
Possible biological names infered from orthology : O14921
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: F
Gene start: 144138654
Gene end: 144177372
  
Corresponding Affymetrix probe sets: 10358399 (MoGene1.0st)   1442263_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058813
Ensembl peptide - ENSMUSP00000107572
NCBI entrez gene - 246709     See in Manteia.
MGI - MGI:2180585
RefSeq - XM_006529613
RefSeq - NM_153171
RefSeq Peptide - NP_694811
swissprot - Q8K443
Ensembl - ENSMUSG00000051079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rgs13ENSDARG00000017653Danio rerio
 si:ch211-117l17.5ENSDARG00000100835Danio rerio
 RGS13ENSGALG00000026810Gallus gallus
 RGS13ENSG00000127074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rgs4 / regulator of G protein signaling 4 / P49798*ENSMUSG0000003853044
Rgs5 / O08850 / regulator of G-protein signaling 5 / O15539*ENSMUSG0000002667841
Rgs2 / O08849 / Regulator of G-protein signaling 2 / P41220*ENSMUSG0000002636041
Rgs1 / Q9JL25 / regulator of G-protein signaling 1 / Q08116*ENSMUSG0000002635841
Rgs3 / Q9DC04 / regulator of G-protein signaling 3 / P49796*ENSMUSG0000005981040
Rgs8 / Q8BXT1 / Mus musculus regulator of G-protein signaling 8 (Rgs8), transcript variant 2, mRNA. / P57771* / regulator of G protein signaling 8*ENSMUSG0000004267140
Rgs18 / Q99PG4 / regulator of G-protein signaling 18 / Q9NS28*ENSMUSG0000002635740
Rgs16 / P97428 / regulator of G-protein signaling 16 / O15492*ENSMUSG0000002647538
Rgs21 / regulator of G protein signaling 21 / Q2M5E4*ENSMUSG0000009850937
Rgs19 / Q9CX84 / regulator of G-protein signaling 19 / P49795*ENSMUSG0000000245836
Rgs20 / Q9QZB1 / regulator of G-protein signaling 20 / O76081*ENSMUSG0000000245935
Rgs17 / Q9QZB0 / regulator of G-protein signaling 17 / Q9UGC6*ENSMUSG0000001977534


Protein motifs (from Interpro)
Interpro ID Name
 IPR016137  RGS domain
 IPR024066  RGS, subdomain 1/3
 IPR034954  Regulator of G-protein signalling 13
 IPR036305  RGS domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IPI
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fjx1tm1Awp/Fjx1+,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fjx1tm1Awp/Fjx1+,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0008483 increased spleen germinal center size "greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

 MP:0008896 increased IgG2c level "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ostm1om/Ostm1om
Genetic Background: C3HeB/FeJ-Ostm1om

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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