ENSMUSG00000026520


Mus musculus

Features
Gene ID: ENSMUSG00000026520
  
Biological name :Pycr2
  
Synonyms : Pycr2 / pyrroline-5-carboxylate reductase family, member 2 / Q922Q4
  
Possible biological names infered from orthology : AL117348.2 / pyrroline-5-carboxylate reductase 2 / Q96C36
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H4
Gene start: 180904293
Gene end: 180908088
  
Corresponding Affymetrix probe sets: 10352306 (MoGene1.0st)   1448315_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027802
NCBI entrez gene - 69051     See in Manteia.
MGI - MGI:1277956
RefSeq - NM_133705
RefSeq Peptide - NP_598466
swissprot - Q3TMZ1
swissprot - Q922Q4
Ensembl - ENSMUSG00000026520
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pycr1aENSDARG00000102254Danio rerio
 pycr1bENSDARG00000098639Danio rerio
 PYCR1ENSGALG00000007300Gallus gallus
 AL117348.2ENSG00000255835Homo sapiens
 PYCR2ENSG00000143811Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pycr1 / Q922W5 / pyrroline-5-carboxylate reductase 1 / P32322*ENSMUSG0000002514081
Pycrl / Q9DCC4 / Pyrroline-5-carboxylate reductase 3 / PYCR3* / Q53H96*ENSMUSG0000002257136


Protein motifs (from Interpro)
Interpro ID Name
 IPR000304  Pyrroline-5-carboxylate reductase
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR029036  Pyrroline-5-carboxylate reductase, dimerisation domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006561 proline biosynthetic process ISO
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0034599 cellular response to oxidative stress ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055129 L-proline biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004735 pyrroline-5-carboxylate reductase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
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Allelic Composition: Ptpn12tm1b(NCOM)Mfgc/Ptpn12tm1b(NCOM)Mfgc
Genetic Background: C57BL/6N-Ptpn12tm1b(NCOM)Mfgc/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026520 Pycr2 / Q922Q4 / pyrroline-5-carboxylate reductase family, member 2 / Q96C36* / AL117348.2* / pyrroline-5-carboxylate reductase 2*  / complex






 

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