ENSMUSG00000025140


Mus musculus

Features
Gene ID: ENSMUSG00000025140
  
Biological name :Pycr1
  
Synonyms : Pycr1 / pyrroline-5-carboxylate reductase 1 / Q922W5
  
Possible biological names infered from orthology : P32322
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 120635712
Gene end: 120643769
  
Corresponding Affymetrix probe sets: 10393887 (MoGene1.0st)   1424556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131199
Ensembl peptide - ENSMUSP00000114863
Ensembl peptide - ENSMUSP00000117737
Ensembl peptide - ENSMUSP00000120558
Ensembl peptide - ENSMUSP00000026133
NCBI entrez gene - 209027     See in Manteia.
MGI - MGI:2384795
RefSeq - XM_011248856
RefSeq - NM_001348222
RefSeq - NM_144795
RefSeq - XM_006532735
RefSeq - XM_011248854
RefSeq - XM_011248855
RefSeq Peptide - NP_659044
RefSeq Peptide - NP_001335151
swissprot - A2ABZ3
swissprot - Q922W5
swissprot - A2ABZ0
swissprot - A2ABZ2
swissprot - Q3UTR5
Ensembl - ENSMUSG00000025140
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pycr1aENSDARG00000102254Danio rerio
 pycr1bENSDARG00000098639Danio rerio
 PYCR1ENSGALG00000007300Gallus gallus
 PYCR1ENSG00000183010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pycr2 / Q922Q4 / pyrroline-5-carboxylate reductase family, member 2 / Q96C36* / AL117348.2* / pyrroline-5-carboxylate reductase 2*ENSMUSG0000002652084
Pycrl / Q9DCC4 / Pyrroline-5-carboxylate reductase 3 / PYCR3* / Q53H96*ENSMUSG0000002257136


Protein motifs (from Interpro)
Interpro ID Name
 IPR000304  Pyrroline-5-carboxylate reductase
 IPR008927  6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
 IPR028939  Pyrroline-5-carboxylate reductase, catalytic, N-terminal
 IPR029036  Pyrroline-5-carboxylate reductase, dimerisation domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006561 proline biosynthetic process ISO
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0034599 cellular response to oxidative stress IEA
 biological_processGO:0051881 regulation of mitochondrial membrane potential IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0055129 L-proline biosynthetic process IEA
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0004735 pyrroline-5-carboxylate reductase activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Amino acid synthesis and interconversion (transamination)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Prkab1tm1b(KOMP)Wtsi/Prkab1tm1b(KOMP)Wtsi
Genetic Background: B6N(Cg)-Prkab1tm1b(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025140 Pycr1 / Q922W5 / pyrroline-5-carboxylate reductase 1 / P32322*  / complex






 

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