ENSMUSG00000026526


Mus musculus

Features
Gene ID: ENSMUSG00000026526
  
Biological name :Fh1
  
Synonyms : Fh1 / Fumarate hydratase, mitochondrial / P97807
  
Possible biological names infered from orthology : FH / fumarate hydratase / P07954
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 175600374
Gene end: 175625635
  
Corresponding Affymetrix probe sets: 10360443 (MoGene1.0st)   1424828_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135385
Ensembl peptide - ENSMUSP00000027810
Ensembl peptide - ENSMUSP00000135140
NCBI entrez gene - 14194     See in Manteia.
MGI - MGI:95530
RefSeq - NM_010209
RefSeq Peptide - NP_034339
swissprot - P97807
swissprot - H3BJV5
swissprot - H3BKG7
Ensembl - ENSMUSG00000026526
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fhENSDARG00000075132Danio rerio
 FHENSGALG00000013165Gallus gallus
 FHENSG00000091483Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000362  Fumarate lyase family
 IPR005677  Fumarate hydratase, class II
 IPR008948  L-Aspartase-like
 IPR018951  Fumarase C, C-terminal
 IPR020557  Fumarate lyase, conserved site
 IPR022761  Fumarate lyase, N-terminal
 IPR024083  Fumarase/histidase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006099 tricarboxylic acid cycle IEA
 biological_processGO:0006106 fumarate metabolic process IEA
 biological_processGO:0006108 malate metabolic process IBA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0045239 tricarboxylic acid cycle enzyme complex IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004333 fumarate hydratase activity IEA
 molecular_functionGO:0016829 lyase activity IEA


Pathways (from Reactome)
Pathway description
Citric acid cycle (TCA cycle)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0003606 kidney failure "cessation of renal function" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0009640 abnormal renal tubule epithelium morphology "any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

 MP:0011308 kidney corticomedullary cysts "development of abnormal membranous sacs in the corticomedullary junction of the kidney" [MGI:anna]
Show

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Tg(HLA-A/H2-D/B2M)1Dvs/0
Genetic Background: NOD.Cg-B2mtm1Unc Tg(HLA-A/H2-D/B2M)1Dvs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026526 Fh1 / P97807 / Fumarate hydratase, mitochondrial / FH* / P07954* / fumarate hydratase*  / complex






 

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