ENSMUSG00000026667


Mus musculus

Features
Gene ID: ENSMUSG00000026667
  
Biological name :Uhmk1
  
Synonyms : P97343 / U2AF homology motif (UHM) kinase 1 / Uhmk1
  
Possible biological names infered from orthology : Q8TAS1 / U2AF homology motif kinase 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 170193420
Gene end: 170215397
  
Corresponding Affymetrix probe sets: 10359961 (MoGene1.0st)   1422136_at (Mouse Genome 430 2.0 Array)   1433737_at (Mouse Genome 430 2.0 Array)   1446120_at (Mouse Genome 430 2.0 Array)   1450500_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120787
Ensembl peptide - ENSMUSP00000027979
Ensembl peptide - ENSMUSP00000115622
NCBI entrez gene - 16589     See in Manteia.
MGI - MGI:1341908
RefSeq - NM_010633
RefSeq - XM_006496682
RefSeq Peptide - NP_034763
swissprot - D3YUF5
swissprot - P97343
swissprot - Q8C0N6
Ensembl - ENSMUSG00000026667
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 uhmk1ENSDARG00000059575Danio rerio
 UHMK1ENSGALG00000002734Gallus gallus
 UHMK1ENSG00000152332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
U2af2 / P26369 / U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2 / P26368* / U2 small nuclear RNA auxiliary factor 2*ENSMUSG0000003043518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR034371  UHMK1, RNA recognition motif
 IPR034372  Serine/threonine-protein kinase Kist
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0045948 positive regulation of translational initiation IMP
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0046825 regulation of protein export from nucleus IEA
 cellular_componentGO:0000243 commitment complex IBA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016607 nuclear speck IBA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0032839 dendrite cytoplasm IDA
 cellular_componentGO:0071004 U2-type prespliceosome IBA
 cellular_componentGO:0071598 neuronal ribonucleoprotein granule IDA
 cellular_componentGO:0089701 U2AF IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008187 poly-pyrimidine tract binding IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030628 pre-mRNA 3"-splice site binding IBA
 molecular_functionGO:0043021 ribonucleoprotein complex binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

 MP:0003091 abnormal cell migration "defect in the movement of cells during developmental processes" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cntn2tm2Furl/Cntn2tm2Furl
Genetic Background: C57BL/6-Cntn2tm2Furl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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