ENSMUSG00000026712


Mus musculus

Features
Gene ID: ENSMUSG00000026712
  
Biological name :Mrc1
  
Synonyms : mannose receptor, C type 1 / Mrc1 / Q61830
  
Possible biological names infered from orthology : P22897
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A2
Gene start: 14229392
Gene end: 14332057
  
Corresponding Affymetrix probe sets: 10469358 (MoGene1.0st)   1450430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028045
NCBI entrez gene - 17533     See in Manteia.
MGI - MGI:97142
RefSeq - NM_008625
RefSeq Peptide - NP_032651
swissprot - Q2HZ94
swissprot - Q61830
Ensembl - ENSMUSG00000026712
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mrc1aENSDARG00000102100Danio rerio
 MMR1L1ENSGALG00000027765Gallus gallus
 MMR1L2ENSGALG00000028357Gallus gallus
 MMR1L3ENSGALG00000008638Gallus gallus
 MMR1L4ENSGALG00000028304Gallus gallus
 MRC1ENSGALG00000008629Gallus gallus
 MRC1ENSG00000260314Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mrc2 / Q64449 / C-type mannose receptor 2 / Q9UBG0* / mannose receptor C type 2*ENSMUSG0000002069533
Pla2r1 / Q62028 / Secretory phospholipase A2 receptor Soluble secretory phospholipase A2 receptor / Q13018* / phospholipase A2 receptor 1*ENSMUSG0000005458029
Ly75 / Q60767 / Lymphocyte antigen 75 / O60449* / LY75-CD302* / LY75-CD302 readthrough*ENSMUSG0000002698026


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000772  Ricin B, lectin domain
 IPR001304  C-type lectin-like
 IPR013806  Kringle-like fold
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR035992  Ricin B-like lectins
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071353 cellular response to interleukin-4 IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0010008 endosome membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IDA
 molecular_functionGO:0005537 mannose binding IDA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
Cross-presentation of soluble exogenous antigens (endosomes)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nr4a2tm1Tpe/Nr4a2+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Mrc1tm1Mnz/Mrc1tm1Mnz,Mrc2tm1Cmi/Mrc2tm1Cmi
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0003369 abnormal circulating estrogen level "aberration in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0010751 decreased susceptibility to parasitic infection induced morbidity/mortality "decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax5tm3Mbu/Pax5+,Tg(Gad1-cre,-lacZ)1Mini/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Pou3f4del-J/Pou3f4del-J
Genetic Background: C3HeB/FeJ-Pou3f4del-J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type






 

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