Manteia

ENSMUSG00000054580

Mus musculus

Features

Gene ID:	ENSMUSG00000054580

Biological name :	Pla2r1

Synonyms :	Pla2r1 / Q62028 / Secretory phospholipase A2 receptor Soluble secretory phospholipase A2 receptor

Possible biological names infered from orthology :	phospholipase A2 receptor 1 / Q13018

Species:	Mus musculus

Chr. number:	2
Strand:	-1
Band:	C1.2
Gene start:	60417543
Gene end:	60553308

Corresponding Affymetrix probe sets:	10482968 (MoGene1.0st) 1450144_at (Mouse Genome 430 2.0 Array) 1454145_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000108144 NCBI entrez gene - 18779 See in Manteia. MGI - MGI:102468 RefSeq - NM_008867 RefSeq - XM_006498928 RefSeq Peptide - NP_032893 swissprot - Q62028 Ensembl - ENSMUSG00000054580

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mrc2 / Q64449 / C-type mannose receptor 2 / Q9UBG0* / mannose receptor C type 2*	ENSMUSG00000020695	32
Ly75 / Q60767 / Lymphocyte antigen 75 / O60449* / LY75-CD302* / LY75-CD302 readthrough*	ENSMUSG00000026980	31
Mrc1 / Q61830 / mannose receptor, C type 1 / P22897*	ENSMUSG00000026712	28

Protein motifs (from Interpro)

Interpro ID	Name
IPR000562	Fibronectin type II domain
IPR000772	Ricin B, lectin domain
IPR001304	C-type lectin-like
IPR016186	C-type lectin-like/link domain superfamily
IPR016187	C-type lectin fold
IPR018378	C-type lectin, conserved site
IPR035992	Ricin B-like lectins
IPR036943	Fibronectin type II domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001816	cytokine production	IEA
biological_process	GO:0006897	endocytosis	IEA
biological_process	GO:0006898	receptor-mediated endocytosis	IDA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator	IEA
biological_process	GO:0072593	reactive oxygen species metabolic process	IEA
biological_process	GO:0090238	positive regulation of arachidonic acid secretion	IDA
biological_process	GO:0090399	replicative senescence	IEA
biological_process	GO:0090403	oxidative stress-induced premature senescence	IEA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0009986	cell surface	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0043235	receptor complex	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IBA
molecular_function	GO:0030246	carbohydrate binding	IEA
molecular_function	GO:0043274	phospholipase binding	IPI

Pathways (from Reactome)

Pathway description

Acyl chain remodelling of PC

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0008734	decreased susceptibility to endotoxin shock	"less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gria2^tm2Rsp/Gria2⁺,Tg(Camk2a-cre)1Gsc/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr