ENSMUSG00000026735


Mus musculus

Features
Gene ID: ENSMUSG00000026735
  
Biological name :Ptf1a
  
Synonyms : pancreas specific transcription factor, 1a / Ptf1a / Q9QX98
  
Possible biological names infered from orthology : Q7RTS3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 19445663
Gene end: 19447501
  
Corresponding Affymetrix probe sets: 10469565 (MoGene1.0st)   1419424_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028068
NCBI entrez gene - 19213     See in Manteia.
MGI - MGI:1328312
RefSeq - NM_018809
RefSeq Peptide - NP_061279
swissprot - A2ATA7
swissprot - Q9QX98
Ensembl - ENSMUSG00000026735
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ptf1aENSDARG00000014479Danio rerio
 PTF1AENSGALG00000027144Gallus gallus
 PTF1AENSG00000168267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ferd3l / Q923Z4 / Fer3-like protein / Q96RJ6* / Fer3 like bHLH transcription factor*ENSMUSG0000004651815


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0009888 tissue development ISS
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0021549 cerebellum development IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030902 hindbrain development IDA
 biological_processGO:0031016 pancreas development ISO
 biological_processGO:0031017 exocrine pancreas development ISS
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0035881 amacrine cell differentiation IMP
 biological_processGO:0045165 cell fate commitment IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048384 retinoic acid receptor signaling pathway IDA
 biological_processGO:0048663 neuron fate commitment IDA
 biological_processGO:0048699 generation of neurons IMP
 biological_processGO:0060042 retina morphogenesis in camera-type eye IMP
 biological_processGO:0061074 regulation of neural retina development IMP
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding ISS
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+,Polr2atm1(cre/ERT2)Bbd/Polr2atm1(cre/ERT2)Bbd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0000850 absent cerebellum "missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Als2tm1Garo/Als2tm1Garo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Als2tm1Garo/Als2tm1Garo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Klbtm1.2Sakl/Klbtm1.2Sakl,Tg(Apoe-Fgf21)1Sakl/0
Genetic Background: involves: 129 * 129S4/SvJaeSor * C57BL/6

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001272 increased metastatic potential 
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ercc2tm2(ERCC2)Jhjh/Ercc2tm2(ERCC2)Jhjh
Genetic Background: involves: 129P2/OlaHsd

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Robo3tm1Matl/Robo3tm1Matl
Genetic Background: Not Specified

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Robo3tm1Matl/Robo3tm1Matl
Genetic Background: Not Specified

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Tal1tm1Por/Tal1tm1Por
Genetic Background: involves: 129P2/OlaHsd

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0001664 abnormal digestion "altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimiliation for synthesis of tissues or liberation of energy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Emx1tm1.1(cre)Ito/Emx1+,Tg(Gfap-GFAP*R239H)60TMIke/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Krastm4Tyj/Kras+,Pdpk1tm1Mlw/Pdpk1tm1Mlw,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/?
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Ednrbtm1Nrd/Ednrbtm1Nrd,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/J

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Psaptm4.1Ggb/Psaptm4.1Ggb
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002111 abnormal tail morphology "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Als2tm1Garo/Als2tm1Garo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Genetic Background: involves: C57BL/6

Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm/Ptf1a/Ptf1aostm3(CAG-Ptf1aos)Kymm
Genetic Background: involves: C57BL/6

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Robo3tm1.1Ache/Robo3tm1.1Ache
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002983 increased retinal ganglion cell number "greater number of cells in the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Ptf1atm1.1Mgn/Ptf1atm1.1Mgn
Genetic Background: Not Specified

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0003119 abnormal digestive system development "dysmorphology of the organ system that converts ingested food to nutrients and energy" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0003245 abnormal GABA neuron morphology "malformation or absence of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Slc40a1tm2Nca/Slc40a1tm2Nca,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003246 loss of GABA neurons "loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Als2tm1Garo/Als2tm1Garo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003247 abnormal glutaminergic neuron "malformation or absence of the neurons that utilize glutamate as a neurotransmitter " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Als2tm1Garo/Als2tm1Garo
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0003334 pancreatic fibrosis "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003338 pancreatic lipomatosis "an accumulation of abnormally localized or tumor-like fat in the pancreas" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003341 chronic pancreas inflammation "persistant inflammatory response in the pancreas, often caused by persistant infection or during an autoimmune response" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003450 enlarged pancreas "increase of the size of the pancreas compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(Pdx1-cre)6Tuv/?
Genetic Background: involves: 129S4/SvJae * FVB/N

Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0003456 absent tail "completely lacking the appendage at the caudal end of the vertebral column " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Genetic Background: involves: C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Gp1bbtm2Frla/Gp1bbtm2Frla
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0003655 absent pancreas "absence of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:20779]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Ptf1atm2Macd/Ptf1atm2Macd
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Etn2Sd/Etn2+,Ptf1a/Ptf1aostm1Kymm/Ptf1a+
Genetic Background: involves: C57BL/6

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

Allelic Composition: Ptf1atm1.1(cre)Cvw/Ptf1a+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Ptf1atm2Macd/Ptf1atm2Macd
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+,Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic Background: involves: 129

Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004704 short vertebral column "decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Genetic Background: involves: C57BL/6

Allelic Composition: Etn2Sd/Etn2+,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a+
Genetic Background: involves: C57BL/6

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0004807 abnormal paired pulse inhibition "defects in the supressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm2Macd/Ptf1atm2Macd
Genetic Background: involves: 129S6/SvEvTac

 MP:0005034 abnormal anus morphology "structural anomaly of the lower opening of the digestive tract" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Genetic Background: involves: C57BL/6

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mcm9Gt(AW0655)Wtsi/Mcm9Gt(XG743)Byg
Genetic Background: involves: 129P2/OlaHsd * C3HeB/FeJ

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Braftm1Sva/Braftm1Sva,Krastm1Bbd/Kras+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Hey1tm1Kkb/Hey1tm1Kkb,Mesp1tm2(cre)Ysa/Mesp1+,Tg(CAG-cat,-Notch1)1Ysa/0
Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * CBA

Allelic Composition: Fat3tm1.2Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(CAG-Bgeo/GFP)21Lbe/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Fat3tm1.1Good/Fat3tm1.2Good,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0006095 absent amacrine cells "absence or loss of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:74753]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

 MP:0006282 abnormal posterior horn morphology "any structural anomaly of the dorsal gray matter of the spinal cord" [J:77764, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm2Macd/Ptf1atm2Macd
Genetic Background: involves: 129S6/SvEvTac

 MP:0006392 abnormal nucleus pulposus morphology "any anomaly in the structure or formation of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Etn2Sd/Etn2Sd,Ptf1a/Ptf1aostm2(Ptf1a)Kymm/Ptf1a/Ptf1aostm2(Ptf1a)Kymm
Genetic Background: involves: C57BL/6

 MP:0008107 absent horizontal cells "absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

 MP:0008508 thick retinal ganglion layer "increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

 MP:0008514 absent retinal inner plexiform layer "absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008571 abnormal synaptic bouton morphology "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Emx1tm1(cre)Ito/Emx1+
Genetic Background: B6.Cg-Emx1tm1(cre)Ito Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0008579 abnormal Purkinje cell differentiation "atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Slc40a1tm2Nca/Slc40a1tm2Nca,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw

Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0009143 abnormal pancreatic duct morphology "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009144 dilated pancreatic duct "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009149 decreased pancreatic acinar cell number "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009151 pancreatic ductal adenocarcinoma "adenocarcinoma that arises from the pancraetic ducts" [MESH:C04.557.470.200.025.232.750]
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Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Smad4tm1Rdp/Smad4tm1Rdp,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129 * FVB/N

Allelic Composition: Cdkn2atm4Rdp/Cdkn2atm4Rdp,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Krastm4Tyj/Kras+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw

Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Krastm4Tyj/Kras+,Raf1tm2Bacc/Raf1tm2Bacc,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Krastm4Tyj/Kras+,Trp53tm1Brn/Trp53tm2Tyj,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0,Trp53tm1Brn/Trp53+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0009152 pancreatic intraepithelial neoplasia "noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct" [PMID:11342768]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Gt(ROSA)26Sortm1(Tva)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw

Allelic Composition: Krastm4Tyj/Krastm4Tyj,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

 MP:0009153 pancreas tumor "tumors or cancer of the pancreas" [MESH:C04.588.274.761]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MUC1)79.24Gend/0
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw Tg(MUC1)79.24Gend

Allelic Composition: Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Krastm4Tyj Ptf1atm1.1(cre)Cvw

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009154 pancreatic acinar hypoplasia "underdevelopment or reduced size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to a decreased cell number" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009156 absent pancreatic acini "absence of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss

 MP:0009165 abnormal endocrine pancreas morphology "any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans" [MESH:A03.734]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0009170 abnormal pancreatic islet size "anomaly in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Sbdstm2.1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Sbdstm1Jrom/Sbdstm3.1Jrom,Ptf1atm1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009179 abnormal pancreatic alpha cell differentiation "atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors" [MESH:A03.734.414.065]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fen1tm1Bhsh/Fen1+
Genetic Background: involves: 129S1/Sv

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptf1atm2Macd/Ptf1atm2Macd
Genetic Background: involves: 129S6/SvEvTac

 MP:0010668 abnormal hepatic portal vein morphology "any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ptf1atm1(cre)Hnak/Ptf1a+,Rbpjtm1Rsch/Rbpjtm1Rsch
Genetic Background: involves: 129X1/SvJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Atp2b2tm1Ges/Atp2b2+
Genetic Background: involves: 129/Sv * 129X1/SvJ * Black Swiss * C3H/HeJ

Allelic Composition: Gt(ROSA)26Sortm1Sor/?,Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Ptf1atm2Macd/Ptf1atm2Macd
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ptf1atm1Pkwe/Ptf1atm1Pkwe
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Cadpstm1.1Tfr/Cadpstm1.2Tfr,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: B6.Cg-Ptf1atm1.1(cre)Cvw Cadpstm1.1Tfr Cadpstm1.2Tfr

 MP:0011934 abnormal branching involved in pancreas development "any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0011935 abnormal pancreatic bud formation "any anomaly in the process in which the foregut region specified to become the pancreas forms a bud" [GO:0061130]
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Allelic Composition: Notch1tm1Agt/Notch1tm1Agt,Notch2tm1Frad/Notch2tm1Frad,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129 * BALB/cJ

 MP:0013184 hemorrhagic ascites "the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity" [MGI:anna]
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Allelic Composition: Krastm4Tyj/Kras+,Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0013221 pancreatic acinar-to-ductal metaplasia "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna]
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Allelic Composition: Gt(ROSA)26Sortm2(Pik3ca*)Dsa/Gt(ROSA)26Sor+,Ptf1atm1(cre)Hnak/Ptf1a+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras*G12D)#Rdp/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Allelic Composition: Smad4tm1.1Gsu/Smad4tm1.1Gsu,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(MtTGFA)Lmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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