ENSMUSG00000026753


Mus musculus

Features
Gene ID: ENSMUSG00000026753
  
Biological name :Ppp6c
  
Synonyms : Ppp6c / Q9CQR6 / Serine/threonine-protein phosphatase 6 catalytic subunit
  
Possible biological names infered from orthology : O00743 / protein phosphatase 6 catalytic subunit
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 39194354
Gene end: 39226451
  
Corresponding Affymetrix probe sets: 10482323 (MoGene1.0st)   1424346_at (Mouse Genome 430 2.0 Array)   1424347_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028087
Ensembl peptide - ENSMUSP00000145393
Ensembl peptide - ENSMUSP00000145157
Ensembl peptide - ENSMUSP00000145064
NCBI entrez gene - 67857     See in Manteia.
MGI - MGI:1915107
RefSeq - XM_006498256
RefSeq - NM_024209
RefSeq Peptide - NP_077171
swissprot - A0A0N4SVL9
swissprot - A0A0N4SW66
swissprot - Q9CQR6
swissprot - A0A0N4SVE2
Ensembl - ENSMUSG00000026753
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp6cENSDARG00000002949Danio rerio
 PPP6CENSGALG00000001013Gallus gallus
 PPP6CENSG00000119414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004843  Calcineurin-like phosphoesterase domain, ApaH type
 IPR006186  Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
 IPR029052  Metallo-dependent phosphatase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001219 thickened epidermis "increase in the width of the epidermal cell layer in the skin" [J:65146]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

 MP:0012572 increased susceptility to chemically induced skin inflammation "decreased dosage threshold or greater inflammatory response of the skin after topical application of chemical irritants" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Crxtm1Clc/Crxtm1Clc,Mef2dtm1.2Tfur/Mef2dtm1.2Tfur
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Ppargtm1b(KOMP)Wtsi/Ppargtm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Ppargtm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024908 Ppp6r3 / Q922D4 / Serine/threonine-protein phosphatase 6 regulatory subunit 3 / Q5H9R7* / protein phosphatase 6 regulatory subunit 3*  / complex
 ENSMUSG00000014496 Q505D1 / Ankrd28 / Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A / O15084* / ankyrin repeat domain 28*  / complex
 ENSMUSG00000036391 Q3U2P1 / Sec24a / Protein transport protein Sec24A / O95486* / SEC24 homolog A, COPII coat complex component*  / reaction
 ENSMUSG00000039234 Sec24d / Sec24 related gene family, member D (S. cerevisiae) / O94855* / SEC24 homolog D, COPII coat complex component*  / reaction
 ENSMUSG00000001052 Sec24b / Sec24 related gene family, member B (S. cerevisiae) / O95487* / SEC24 homolog B, COPII coat complex component*  / reaction
 ENSMUSG00000052296 Ppp6r1 / Q7TSI3 / Serine/threonine-protein phosphatase 6 regulatory subunit 1 / Q9UPN7* / protein phosphatase 6 regulatory subunit 1*  / complex






 

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