ENSMUSG00000026825


Mus musculus

Features
Gene ID: ENSMUSG00000026825
  
Biological name :Dnm1
  
Synonyms : Dnm1 / Dynamin-1 / P39053
  
Possible biological names infered from orthology : Q05193
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 32308471
Gene end: 32353338
  
Corresponding Affymetrix probe sets: 10481592 (MoGene1.0st)   1427754_a_at (Mouse Genome 430 2.0 Array)   1460365_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143955
Ensembl peptide - ENSMUSP00000122679
Ensembl peptide - ENSMUSP00000144145
Ensembl peptide - ENSMUSP00000144309
Ensembl peptide - ENSMUSP00000144264
Ensembl peptide - ENSMUSP00000077461
Ensembl peptide - ENSMUSP00000088618
Ensembl peptide - ENSMUSP00000108977
Ensembl peptide - ENSMUSP00000108979
Ensembl peptide - ENSMUSP00000108992
Ensembl peptide - ENSMUSP00000115523
Ensembl peptide - ENSMUSP00000116054
Ensembl peptide - ENSMUSP00000118855
Ensembl peptide - ENSMUSP00000118914
NCBI entrez gene - 13429     See in Manteia.
MGI - MGI:107384
RefSeq - XM_017315328
RefSeq - XM_006497651
RefSeq - XM_006497652
RefSeq - XM_006497653
RefSeq - XM_006497654
RefSeq - XM_006497655
RefSeq - XM_006497658
RefSeq - XM_006497659
RefSeq - XM_006497660
RefSeq - XM_006497661
RefSeq - XM_006497662
RefSeq - NM_001301737
RefSeq - NM_010065
RefSeq - XM_006497649
RefSeq - XM_006497650
RefSeq Peptide - NP_001288666
RefSeq Peptide - NP_034195
swissprot - F6RRH9
swissprot - F6TH70
swissprot - F6W8Z8
swissprot - D6RH60
swissprot - P39053
swissprot - A0A0J9YUE9
swissprot - A0A0J9YUN4
swissprot - A0A0J9YUS0
Ensembl - ENSMUSG00000026825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnm1aENSDARG00000010042Danio rerio
 dnm1bENSDARG00000009281Danio rerio
 DNM1ENSGALG00000004852Gallus gallus
 DNM1ENSG00000106976Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*ENSMUSG0000003333581
Dnm3 / Q8BZ98 / Dynamin-3 / Q9UQ16*ENSMUSG0000004026580
Dnm1l / Q8K1M6 / Dynamin-1-like protein / O00429* / dynamin 1 like*ENSMUSG0000002278935
Mx2 / Q9WVP9 / Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA. / MX1* / P20591* / MX dynamin like GTPase 1*ENSMUSG0000002334122
Mx1 / MX dynamin-like GTPase 1 / P20591*ENSMUSG0000000038614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR001849  Pleckstrin homology domain
 IPR003130  Dynamin GTPase effector
 IPR011993  PH-like domain superfamily
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR027741  Dynamin-1
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IBA
 biological_processGO:0002031 G-protein coupled receptor internalization IEA
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IBA
 biological_processGO:0006897 endocytosis ISO
 biological_processGO:0006898 receptor-mediated endocytosis ISO
 biological_processGO:0007032 endosome organization ISO
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane IGI
 biological_processGO:0031623 receptor internalization IEA
 biological_processGO:0051262 protein tetramerization IMP
 biological_processGO:0051932 synaptic transmission, GABAergic IMP
 biological_processGO:0061025 membrane fusion IBA
 biological_processGO:0072583 clathrin-dependent endocytosis IEA
 biological_processGO:1901998 toxin transport IMP
 biological_processGO:1903423 positive regulation of synaptic vesicle recycling IEA
 cellular_componentGO:0001917 photoreceptor inner segment IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008021 synaptic vesicle IEA
 cellular_componentGO:0030117 membrane coat IDA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 cellular_componentGO:0043196 varicosity IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0031749 D2 dopamine receptor binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0046983 protein dimerization activity IDA
 molecular_functionGO:0050998 nitric-oxide synthase binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Gap junction degradation
Formation of annular gap junctions
MHC class II antigen presentation
Recycling pathway of L1
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnm1Ftfl/Dnm1tm1Pdc
Genetic Background: involves: C57BL/6J

 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
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Allelic Composition: Dnm1Ftfl/Dnm1Ftfl
Genetic Background: C57BL/6J-Dnm1Ftfl

 MP:0001505 hunched posture "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404]
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Allelic Composition: Dnm1Ftfl/Dnm1tm1Pdc
Genetic Background: involves: C57BL/6J

Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Dnm1Ftfl/Dnm1Ftfl
Genetic Background: C57BL/6J-Dnm1Ftfl

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

Allelic Composition: Dnm1Ftfl/Dnm1tm2.2Frk
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Dnm1Ftfl/Dnm1+
Genetic Background: FVB.B6-Dnm1Ftfl/Frk

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Dnm1Ftfl/Dnm1tm1Pdc
Genetic Background: involves: C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gnetm1.1Masn/Gnetm1.1Masn
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Cdh5-cre/ERT2)#Ykub/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Dnm1tm2.1Pdc/Dnm1tm2.1Pdc,Dnm2tm1.1Pdc/Dnm2tm1.1Pdc,Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Pax6-cre,GFP)2Pgr/0
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * C57BL/6

 MP:0002826 tonic seizures "increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1Ftfl/Dnm1Ftfl
Genetic Background: C57BL/6J-Dnm1Ftfl

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0003491 abnormal voluntary movement "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004769 abnormal synaptic vesicle morphology "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004770 abnormal synaptic vesicle recycling "any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kcne2tm1a(EUCOMM)Wtsi/Kcne2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Kcne2tm1a(EUCOMM)Wtsi

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: BcorGt(W096D07)Wrst/Y
Genetic Background: chimera involves: 129S2/SvPas

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
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Allelic Composition: Kdrtm2.1Jrt/Kdrtm2.1Jrt,Tg(Cdh5-cre/ERT2)#Ykub/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col4a2ENU4020/Col4a2+
Genetic Background: C3.D2-Col4a2ENU4020

Allelic Composition: Dnm1Ftfl/Dnm1Ftfl,Tg(Pvalb-EGFP)B20Zjh/0
Genetic Background: involves: C57BL/6 * C57BL/6J * FVB

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

Allelic Composition: Dnm1Ftfl/Dnm1Ftfl
Genetic Background: C57BL/6J-Dnm1Ftfl

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0011270 decreased excitatory postsynaptic current amplitude "reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave" [MGI:csmith]
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Allelic Composition: Dnm1tm1Pdc/Dnm1tm1Pdc,Dnm3tm1.2Pdc/Dnm3tm1.2Pdc
Genetic Background: involves: 129S1/Sv * C57BL/6 * FVB/N

 MP:0011966 abnormal auditory brainstem response waveform shape "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith]
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Allelic Composition: Dnm1Ftfl/Dnm1Ftfl
Genetic Background: C57BL/6J-Dnm1Ftfl

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Dnm1Ftfl/Dnm1Ftfl
Genetic Background: C57BL/6J-Dnm1Ftfl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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