ENSMUSG00000022789


Mus musculus

Features
Gene ID: ENSMUSG00000022789
  
Biological name :Dnm1l
  
Synonyms : Dnm1l / Dynamin-1-like protein / Q8K1M6
  
Possible biological names infered from orthology : dynamin 1 like / O00429
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A2
Gene start: 16312230
Gene end: 16358959
  
Corresponding Affymetrix probe sets: 10437992 (MoGene1.0st)   1428008_at (Mouse Genome 430 2.0 Array)   1428086_at (Mouse Genome 430 2.0 Array)   1428087_at (Mouse Genome 430 2.0 Array)   1452638_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155605
Ensembl peptide - ENSMUSP00000155155
Ensembl peptide - ENSMUSP00000155429
Ensembl peptide - ENSMUSP00000023477
Ensembl peptide - ENSMUSP00000093945
Ensembl peptide - ENSMUSP00000111415
NCBI entrez gene - 74006     See in Manteia.
MGI - MGI:1921256
RefSeq - XM_017317141
RefSeq - NM_001025947
RefSeq - NM_001276340
RefSeq - NM_001276341
RefSeq - NM_152816
RefSeq - XM_006522635
RefSeq - XM_006522636
RefSeq - XM_006522637
RefSeq - XM_006522638
RefSeq - XM_006522639
RefSeq - XM_017317140
RefSeq - XM_006522628
RefSeq - XM_006522629
RefSeq - XM_006522630
RefSeq - XM_006522631
RefSeq - XM_006522632
RefSeq - XM_006522633
RefSeq - XM_006522634
RefSeq Peptide - NP_001021118
RefSeq Peptide - NP_001263269
RefSeq Peptide - NP_001263270
RefSeq Peptide - NP_690029
swissprot - Q8K1M6
swissprot - E9PUD2
Ensembl - ENSMUSG00000022789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnm1lENSDARG00000015006Danio rerio
 DNM1LENSGALG00000012929Gallus gallus
 DNM1LENSG00000087470Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dnm2 / P39054 / Mus musculus dynamin 2 (Dnm2), transcript variant 5, mRNA. / P50570* / dynamin 2*ENSMUSG0000003333542
Dnm1 / P39053 / Dynamin-1 / Q05193*ENSMUSG0000002682542
Dnm3 / Q8BZ98 / Dynamin-3 / Q9UQ16*ENSMUSG0000004026541
Mx2 / Q9WVP9 / Mus musculus MX dynamin-like GTPase 2 (Mx2), transcript variant 1, mRNA. / MX1* / P20591* / MX dynamin like GTPase 1*ENSMUSG0000002334124
Mx1 / MX dynamin-like GTPase 1 / P20591*ENSMUSG0000000038616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000375  Dynamin central domain
 IPR001401  Dynamin, GTPase domain
 IPR003130  Dynamin GTPase effector
 IPR019762  Dynamin, GTPase region, conserved site
 IPR020850  GTPase effector domain
 IPR022812  Dynamin superfamily
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030381  Dynamin-type guanine nucleotide-binding (G) domain
 IPR030556  Dynamin-1-like protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000266 mitochondrial fission IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IMP
 biological_processGO:0003374 dynamin family protein polymerization involved in mitochondrial fission IDA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0007005 mitochondrion organization IMP
 biological_processGO:0010637 negative regulation of mitochondrial fusion IMP
 biological_processGO:0010821 regulation of mitochondrion organization IMP
 biological_processGO:0012501 programmed cell death IEA
 biological_processGO:0016559 peroxisome fission IEA
 biological_processGO:0032459 regulation of protein oligomerization IDA
 biological_processGO:0036466 synaptic vesicle recycling via endosome IMP
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043653 mitochondrial fragmentation involved in apoptotic process IMP
 biological_processGO:0048312 intracellular distribution of mitochondria IMP
 biological_processGO:0050714 positive regulation of protein secretion IDA
 biological_processGO:0051259 protein complex oligomerization IMP
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051289 protein homotetramerization IDA
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IMP
 biological_processGO:0061025 membrane fusion IDA
 biological_processGO:0070266 necroptotic process IMP
 biological_processGO:0070584 mitochondrion morphogenesis IMP
 biological_processGO:0070585 protein localization to mitochondrion IMP
 biological_processGO:0071396 cellular response to lipid IEP
 biological_processGO:0090141 positive regulation of mitochondrial fission IMP
 biological_processGO:0090149 mitochondrial membrane fission IDA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IMP
 biological_processGO:0090650 cellular response to oxygen-glucose deprivation IEP
 biological_processGO:1900063 regulation of peroxisome organization IMP
 biological_processGO:1900244 positive regulation of synaptic vesicle endocytosis IMP
 biological_processGO:1903146 regulation of autophagy of mitochondrion IGI
 biological_processGO:1903578 regulation of ATP metabolic process IMP
 biological_processGO:1904579 cellular response to thapsigargin IMP
 biological_processGO:1905395 response to flavonoid IEP
 biological_processGO:1990910 response to hypobaric hypoxia IEP
 biological_processGO:2000302 positive regulation of synaptic vesicle exocytosis IMP
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0000139 Golgi membrane IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005741 mitochondrial outer membrane IDA
 cellular_componentGO:0005777 peroxisome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005874 microtubule IDA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005905 clathrin-coated pit IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030672 synaptic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031966 mitochondrial membrane IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0098794 postsynapse IEA
 cellular_componentGO:0099073 mitochondrion-derived vesicle IDA
 cellular_componentGO:0099503 secretory vesicle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008017 microtubule binding IBA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017137 Rab GTPase binding IDA
 molecular_functionGO:0030276 clathrin binding IPI
 molecular_functionGO:0030742 GTP-dependent protein binding IDA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0051433 BH2 domain binding IPI


Pathways (from Reactome)
Pathway description
Apoptotic execution phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0000367 abnormal coat/ hair morphology "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0000597 delayed hepatic development "late onset of the induction and/or differentiation of the liver" [J:18048]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000784 forebrain hypoplasia "reduced cell number in the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pkdcctm1.1Mask/Pkdcctm1.1Mask
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lasp1Tg(Col1a1-lacZ)1Ngma/Lasp1Tg(Col1a1-lacZ)1Ngma,Pax1un-ex/Pax1un-ex
Genetic Background: involves: C57BL/6

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0001492 piloerection "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0001714 absent trophoblast cells "missing cells of the extraembryonic cell layer that contribute to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33880]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Pkdcctm1.1Mask/Pkdcctm1.1Mask
Genetic Background: involves: C57BL/6 * CBA * FVB/N

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0004998 decreased CNS synapse formation "a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0005277 abnormal brainstem morphology "anomalous structure of the midbrain, pons, or medulla" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82670]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0005324 ascites "accumulation or retention of fluid within the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0005426 tachypnea "rapid breathing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH * C57BL/6J

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0008775 abnormal heart ventricular pressure "any anomaly in the pressure within a cardiac ventricle" [MESH:G09.330.553.660.937]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0009027 abnormal subarachnoid space morphology "any structural anomaly of the space between the arachnoid and dura mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0009719 reduced cerebellar foliation "the cerebellar lobules are reduced in size or number" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0010017 visceral vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0010018 lung vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the lung" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0010334 pleural effusion "accumulation of excess fluid in the pleural cavity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0010956 abnormal mitochondrial ATP synthesis coupled electron transport "anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV" [GO:0042775, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dnm1lPy/Dnm1l+
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.1Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dnase1l2tm1.1(KOMP)Wtsi/Dnase1l2tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Dnase1l2tm1.1(KOMP)Wtsi/J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
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Allelic Composition: Dnm1ltm1.1Hise/Dnm1ltm1.2Hise,En1tm2(cre)Wrst/En1+
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0011705 absent fibroblast proliferation "failure of a fibroblast cell population to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Dnm1lPy/Dnm1lPy
Genetic Background: involves: BALB/cAnNCrl * C3H/HeH

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0014010 abnormal peroxisome morphology "any structural anomaly of a small cytoplasmic organelle enclosed by a single membrane that contains peroxidases and other enzymes which are important for a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism" [GO:0005777]
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Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0014178 increased brain apoptosis "increase in the number of cells of the brain undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Dnm1ltm1.2Miha/Dnm1ltm1.2Miha
Genetic Background: involves: C57BL/6J

 MP:0030309 abnormal posterior cranial fossa morphology "any structural anomaly of the most inferior and deepest of the cranial fossae, located between the foramen magnum and tentorium cerebelli, which houses the brainstem and cerebellum; it is bounded anteriorly and medially by the dorsum sellae of the sphenoid bone; anteriorly and laterally by the superior border of the petrous part of the temporal bone; and posteriorly by the internal surface of the squamous part of the occipital bone; its floor consists of the mastoid part of the temporal bone and the squamous, condylar and basilar parts of the occipital bone" [http://teachmeanatomy.info/head/areas/cranial-fossa/posterior/, https://radiopaedia.org/articles/posterior-cranial-fossa]
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Allelic Composition: Dnm1ltm1.1Miha/Dnm1ltm1.1Miha,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * C57BL/6J * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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