ENSMUSG00000027030


Mus musculus

Features
Gene ID: ENSMUSG00000027030
  
Biological name :Stk39
  
Synonyms : Q9Z1W9 / STE20/SPS1-related proline-alanine-rich protein kinase / Stk39
  
Possible biological names infered from orthology : Q9UEW8 / serine/threonine kinase 39
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 68210445
Gene end: 68472268
  
Corresponding Affymetrix probe sets: 10483381 (MoGene1.0st)   1419550_a_at (Mouse Genome 430 2.0 Array)   1419551_s_at (Mouse Genome 430 2.0 Array)   1431434_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099776
NCBI entrez gene - 53416     See in Manteia.
MGI - MGI:1858416
RefSeq - XM_017319130
RefSeq - NM_016866
RefSeq - XM_011239693
RefSeq - XM_017319128
RefSeq - XM_017319129
RefSeq Peptide - NP_058562
swissprot - Q9Z1W9
swissprot - A2AQL0
Ensembl - ENSMUSG00000027030
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 stk39ENSDARG00000087203Danio rerio
 STK39ENSGALG00000010930Gallus gallus
 STK39ENSG00000198648Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Oxsr1 / Q6P9R2 / Serine/threonine-protein kinase OSR1 / O95747* / oxidative stress responsive 1*ENSMUSG0000003673770
Q3UUJ4 / Strada / STE20-related kinase adapter protein alpha / Q7RTN6* / STE20-related kinase adaptor alpha*ENSMUSG0000006963120
Q8K4T3 / Stradb / STE20-related kinase adapter protein beta / Q9C0K7* / STE20-related kinase adaptor beta*ENSMUSG0000002602719


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity ISS
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008217 regulation of blood pressure IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation ISO
 biological_processGO:0018107 peptidyl-threonine phosphorylation IGI
 biological_processGO:0023014 signal transduction by protein phosphorylation ISO
 biological_processGO:0023016 signal transduction by trans-phosphorylation ISO
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0032414 positive regulation of ion transmembrane transporter activity IEA
 biological_processGO:0035556 intracellular signal transduction IGI
 biological_processGO:0036438 maintenance of lens transparency IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043268 positive regulation of potassium ion transport IEA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0050727 regulation of inflammatory response IDA
 biological_processGO:0071476 cellular hypotonic response IGI
 biological_processGO:0090188 negative regulation of pancreatic juice secretion IMP
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity ISO
 biological_processGO:1901380 negative regulation of potassium ion transmembrane transport IGI
 biological_processGO:1905408 negative regulation of creatine transmembrane transporter activity ISO
 biological_processGO:2000650 negative regulation of sodium ion transmembrane transporter activity ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IGI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

Allelic Composition: Stk39tm1.2Slin/Stk39+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptpn11tm6Bgn/Ptpn11+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

 MP:0002986 hypocalciuria "excretion of abnormally low amounts of calcium in the urine" [J:83000]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

Allelic Composition: Stk39tm1.1Arte/Stk39tm1.1Arte
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0003916 decreased left ventricle weight "less than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39tm1.1Arte
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Gata4tm1Sho/Gata4tm1.1Wtp,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39tm1.1Arte
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0004879 decreased systemic vascular resistance "reduction in the normal force opposing blood flow in the peripheral blood vessels" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

Allelic Composition: Stk39tm1.1Arte/Stk39tm1.1Arte
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39tm1.1Arte
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

 MP:0010093 decreased circulating magnesium level "a reduction in the blood concentration of magnesium" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

Allelic Composition: Stk39tm1.1Arte/Stk39tm1.1Arte
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

 MP:0011435 increased urine magnesium level "higher than normal amount of magnesium in the urine" [MGI:anna]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Col13a1tm3.1Pih/Col13a1tm3.1Pih
Genetic Background: involves: C57BL/6

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
Show

Allelic Composition: Stk39tm2.1Arte/Stk39tm2.1Arte
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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