ENSMUSG00000036737


Mus musculus

Features
Gene ID: ENSMUSG00000036737
  
Biological name :Oxsr1
  
Synonyms : Oxsr1 / Q6P9R2 / Serine/threonine-protein kinase OSR1
  
Possible biological names infered from orthology : O95747 / oxidative stress responsive 1
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 119238432
Gene end: 119322427
  
Corresponding Affymetrix probe sets: 10597627 (MoGene1.0st)   1426933_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122692
Ensembl peptide - ENSMUSP00000042155
Ensembl peptide - ENSMUSP00000117327
NCBI entrez gene - 108737     See in Manteia.
MGI - MGI:1917378
RefSeq - XM_006511919
RefSeq - XM_006511920
RefSeq - NM_133985
RefSeq Peptide - NP_598746
swissprot - Q6P9R2
swissprot - F7AVI9
swissprot - D6RFV0
Ensembl - ENSMUSG00000036737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 oxsr1aENSDARG00000034189Danio rerio
 oxsr1bENSDARG00000027500Danio rerio
 OXSR1ENSGALG00000005979Gallus gallus
 OXSR1ENSG00000172939Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stk39 / Q9Z1W9 / STE20/SPS1-related proline-alanine-rich protein kinase / Q9UEW8* / serine/threonine kinase 39*ENSMUSG0000002703074
Q3UUJ4 / Strada / STE20-related kinase adapter protein alpha / Q7RTN6* / STE20-related kinase adaptor alpha*ENSMUSG0000006963122
Q8K4T3 / Stradb / STE20-related kinase adapter protein beta / Q9C0K7* / STE20-related kinase adaptor beta*ENSMUSG0000002602721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR024678  Serine/threonine-protein kinase OSR1/WNK, CCT domain
 IPR028749  Serine/threonine-protein kinase OSR1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006979 response to oxidative stress IDA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0071476 cellular hypotonic response IGI
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IGI
 biological_processGO:1901380 negative regulation of potassium ion transmembrane transport IGI
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IGI
 molecular_functionGO:0004702 obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Fstl1tm2.1(cre/ERT2)Mvdh/Fstl1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fstl1tm2.1(cre/ERT2)Mvdh/Fstl1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0005441 hypercalciuria "excretion of abnormally large amounts of calcium in the urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:86949]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oxsr1tm1.1Ssy/Oxsr1tm1.1Ssy,Tg(Cdh16-cre)91Igr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Il2m1/Il2m1
Genetic Background: MRL/MpJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Stk39tm1.1Arte/Stk39+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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