ENSMUSG00000027048


Mus musculus

Features
Gene ID: ENSMUSG00000027048
  
Biological name :Abcb11
  
Synonyms : Abcb11 / ATP-binding cassette, sub-family B (MDR/TAP), member 11 / Q9QY30
  
Possible biological names infered from orthology : ATP binding cassette subfamily B member 11 / O95342
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C2
Gene start: 69238282
Gene end: 69342616
  
Corresponding Affymetrix probe sets: 10483410 (MoGene1.0st)   1449817_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099770
Ensembl peptide - ENSMUSP00000099771
Ensembl peptide - ENSMUSP00000137017
NCBI entrez gene - 27413     See in Manteia.
MGI - MGI:1351619
RefSeq - NM_021022
RefSeq - XM_006499669
RefSeq - XM_006499670
RefSeq Peptide - NP_066302
swissprot - J3QNY6
swissprot - Q9QY30
Ensembl - ENSMUSG00000027048
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb11bENSDARG00000070078Danio rerio
 ABCB11ENSGALG00000010891Gallus gallus
 ABCB11ENSG00000073734Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb1a / P21447 / Multidrug resistance protein 1A / ABCB1* / P08183* / ATP binding cassette subfamily B member 1*ENSMUSG0000004058447
Abcb1b / P06795 / ATP-binding cassette, sub-family B (MDR/TAP), member 1B / ABCB1* / P08183* / ATP binding cassette subfamily B member 1*ENSMUSG0000002897047
Abcb4 / P21440 / Phosphatidylcholine translocator ABCB4 / P21439* / ATP binding cassette subfamily B member 4*ENSMUSG0000004247646
Abcb5 / B5X0E4 / ATP-binding cassette, sub-family B (MDR/TAP), member 5 / Q2M3G0* / ATP binding cassette subfamily B member 5*ENSMUSG0000007279142


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030278  Bile salt export pump
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0015721 bile acid and bile salt transport IEA
 biological_processGO:0015722 canalicular bile acid transport IBA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0046581 intercellular canaliculus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0015126 canalicular bile acid transmembrane transporter activity IBA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
Recycling of bile acids and salts
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Zfp106tm1a(KOMP)Wtsi/Wtsi

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Zfp106tm1a(KOMP)Wtsi/Wtsi

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Zfp106tm1a(KOMP)Wtsi/Wtsi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Zfp106tm1a(KOMP)Wtsi/Wtsi

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004772 abnormal bile secretion "any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004774 abnormal bile salt level "anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004789 increased bile salt level "increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary sytem as bile salts; these play an important role in the digestion and absorption of fats" [MESH:D04.808.105, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Zfp106tm1a(KOMP)Wtsi/Wtsi

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005439 decreased glycogen level "less than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Zfp106tm1a(KOMP)Wtsi/Zfp106tm1a(KOMP)Wtsi
Genetic Background: B6JTyr;B6N-Zfp106tm1a(KOMP)Wtsi/Wtsi

 MP:0008991 abnormal bile canaliculus morphology "any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Vdac1tm1Wjc/Vdac1tm1Wjc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Abca1tm1b(EUCOMM)Hmgu/Abca1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Abca1tm1b(EUCOMM)Hmgu/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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